Seroatlas · Human Serome Atlas

SPDYE21

Speedy protein E21

Also known as: SPD21_HUMAN, SPDYE21P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A494C086
Gene: SPDYE21
Ensembl: ENSG00000230358
Chromosome: 7
Canonical length: 402 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable protein kinase binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

402 residues, UniProt reviewed canonical sequence.

>A0A494C086|SPDYE21
     1  MDRTETRFRK RGQITGKITT SRQLHPQNEQ SPQRSTSGYP LQEVVDDEVL GPSAPGVDPS
    61  PPCRSLGWKR KKEWSDESEE EPEKELAPEP EETWVVETLC GLKMKLKQQR VSPILPEHHK
   121  DFNSQLAPGV DPSPPHRSFC WKRKREWWDE SEESLEEEPR KVLAPEPEEI WVAEMLCGLK
   181  MKLKRRRVLL VLPEHHEAFN RLLEDPVIKR FLAWDKDLRV SDKYLLAMVI VYFSRAGLPS
   241  WQYQRIHFFL ALYLANDMEE DDEDSKQNIF HFLYGKTRSR IPLLRKRWFQ LGRSMNPRAR
   301  KNRSRIPLLR KRRFQLGRSM NPRARKYRSR IPLVRKRRFQ LRRCMNPRAR KNRSQIVLFQ
   361  KLRFQFFCSM SGRAWVSPEE LEEIQAYDPE HWVWARDRAH LS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPDYE21 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 0.8 nTPM

Expression across tissuesHPA

Tissue

testis: 0.8 nTPM
skin: 0.4 nTPM
bone marrow: 0.2 nTPM
lymph node: 0.2 nTPM
prostate: 0.2 nTPM
retina: 0.2 nTPM

Single-cell type

myonuclei: 50 nCPM
ovarian stromal cells: 45 nCPM
goblet cells: 45 nCPM
sertoli cells: 41 nCPM
cardiomyocytes: 40 nCPM
cytotrophoblasts: 40 nCPM

Immune cell

basophil: 0.6 nTPM
non-classical monocyte: 0.3 nTPM
gdT-cell: 0.2 nTPM
MAIT T-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM

Brain region

cerebellum: 6.8 nTPM
amygdala: 6.5 nTPM
basal ganglia: 6 nTPM
cerebral cortex: 5.6 nTPM
thalamus: 5.5 nTPM
hypothalamus: 5.4 nTPM

OntologyGO

Molecular functions

protein kinase binding

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPDYE21 as an antibody target. Whether an autoantibody or antibody against SPDYE21 could matter depends on whether native SPDYE21 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPDYE21 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPDYE21 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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