Seroatlas · Human Serome Atlas

SPDYE2

Speedy protein E2

Also known as: MGC119295, SPDE2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q495Y8
Gene: SPDYE2
Ensembl: ENSG00000205238
Chromosome: 7
Canonical length: 402 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable protein kinase binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

402 residues, UniProt reviewed canonical sequence.

>Q495Y8|SPDYE2
     1  MDRTETRFRK RGQITGKITT SRQPHPQNEQ SPQRSTSGYP LQEVVDDEML GPSAPGVDPS
    61  PPCRSLGWKR KREWSDESEE EPEKELAPEP EETWVVEMLC GLKMKLKQQR VSPILPEHHK
   121  DFNSQLAPGV DPSPPHRSFC WKRKMEWWDE SEESLEEEPR KVLAPEPEEI WVAEMLCGLK
   181  MKLKRRRVSL VLPEHHEAFN RLLEDPVIKR FLAWDKDLRV SDKYLLAMVI AYFSRAGFPS
   241  WQYQRIHFFL ALYLANDMEE DDEDSKQNIF HFLYRKNRSR IPLLRKPWFQ LGHSMNPRAR
   301  KNRSRIPLLR KRRFQLYRST NPRARKNRSR IPLLRKRRFQ LYRSMNSRAR KNRSQIVLFQ
   361  KRRFHFFCSM SCRAWVSPEE LEEIQAYDPE HWVWARDRAH LS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPDYE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 4.1 nTPM

Expression across tissuesHPA

Tissue

testis: 4.1 nTPM
bone marrow: 3.9 nTPM
skeletal muscle: 3.9 nTPM
appendix: 3.1 nTPM
skin: 2.8 nTPM
lymph node: 2.7 nTPM

Single-cell type

myonuclei: 168 nCPM
syncytiotrophoblasts: 141 nCPM
cholangiocytes: 126 nCPM
cytotrophoblasts: 108 nCPM
migrating cytotrophoblasts: 93 nCPM
enterocytes: 93 nCPM

Immune cell

neutrophil: 0.4 nTPM
gdT-cell: 0.3 nTPM
plasmacytoid DC: 0.3 nTPM
classical monocyte: 0.2 nTPM
naive B-cell: 0.2 nTPM
basophil: 0.1 nTPM

Brain region

cerebellum: 21 nTPM
white matter: 20 nTPM
cerebral cortex: 19 nTPM
medulla oblongata: 18 nTPM
hypothalamus: 18 nTPM
thalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.48
gnomAD pLI: 0.47
gnomAD missense Z: 0.33

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

protein kinase binding

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPDYE2 as an antibody target. Whether an autoantibody or antibody against SPDYE2 could matter depends on whether native SPDYE2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPDYE2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPDYE2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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