Seroatlas · Human Serome Atlas

SPDYE18

Speedy protein E18

Also known as: SPD18_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DV79
Gene: SPDYE18
Ensembl: ENSG00000205482
Chromosome: 7
Canonical length: 352 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable protein kinase binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

352 residues, UniProt reviewed canonical sequence.

>P0DV79|SPDYE18
     1  MDRTKTRFRK RGQITGKITT SRQPHPQNEQ SLQRSTSGYP LQEVVDDEVL GPSAPGVDPS
    61  PPCRSLGWKR KKEWSDESEE EPEKELAPEP EETWVVEMLC GLKMKLKQQR VSPILPEHHK
   121  DFNSQLAPGV DPSPPHRSFC WKRKREWWDE SEESLEEEPR KVLAPEPEEI WVAEMLCGLK
   181  MKLKRRRVSL VLPEHHEAFN RLLEDPVIKR FLAWDKDLRV SDKYLLAMVI AYFSRAGLPS
   241  WQYQRIHFFL ALYLANDMEE DDEDPKQNIF YFLYGKTRSR IPLVRNRRFQ LCRCLNPRAR
   301  KNRSQIALFQ KLRFQFFCSM SGRAWVSREE LEEIQAYDPE HWVWARDRAR LS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPDYE18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 4.5 nTPM

Expression across tissuesHPA

Tissue

retina: 4.5 nTPM
testis: 2.2 nTPM
skin: 2.1 nTPM
ovary: 1.6 nTPM
thyroid gland: 1.4 nTPM
epididymis: 1.3 nTPM

Single-cell type

sertoli cells: 111 nCPM
epicardial cells: 77 nCPM
late spermatids: 62 nCPM
suprabasal keratinocytes: 39 nCPM
early spermatids: 39 nCPM
basal keratinocytes: 28 nCPM

Immune cell

neutrophil: 0.4 nTPM
T-reg: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

white matter: 5.5 nTPM
choroid plexus: 4.8 nTPM
cerebral cortex: 4.5 nTPM
basal ganglia: 4.4 nTPM
thalamus: 4.4 nTPM
midbrain: 4.3 nTPM

OntologyGO

Molecular functions

protein kinase binding

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPDYE18 as an antibody target. Whether an autoantibody or antibody against SPDYE18 could matter depends on whether native SPDYE18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPDYE18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPDYE18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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