Seroatlas · Human Serome Atlas

SPDYE17

Speedy protein E17

Also known as: SPD17_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DUD2
Gene: SPDYE17
Ensembl: ENSG00000186645
Chromosome: 7
Canonical length: 265 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables acetylcholine receptor regulator activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

265 residues, UniProt reviewed canonical sequence.

>P0DUD2|SPDYE17
     1  MGQILGKIMM SHQPQPQEER SPQRSTSGYP LQEVVDDEVS GPSAPGVDPS PPRRSLGWKR
    61  KRECLDESDD EPEKELAPEP EETWVAETLC GLKMKAKRRR VSLVLPEYYE AFNRLLEDPV
   121  IKRLLAWDKD LRVSDKYLLA MVIAYFSRAG LPSWQYQRIH FFLALYLAND MEEDDEAPKQ
   181  NIFYFLYEET RSHIPLLSEL WFQLCRYMNP RARKNCSQIA LFRKYRFHFF CSMRCRAWVS
   241  LEELEEIQAY DPEHWVWARD RAHLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPDYE17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 0.8 nTPM

Expression across tissuesHPA

Tissue

testis: 0.8 nTPM
skin: 0.4 nTPM
appendix: 0.1 nTPM
esophagus: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

sertoli cells: 22 nCPM
microglia: 16 nCPM
early spermatids: 14 nCPM
epicardial cells: 14 nCPM
paneth cells: 12 nCPM
oligodendrocyte progenitor cells: 12 nCPM

Immune cell

plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 1.1 nTPM
thalamus: 1.1 nTPM
medulla oblongata: 1 nTPM
midbrain: 1 nTPM
white matter: 1 nTPM
basal ganglia: 0.9 nTPM

OntologyGO

Molecular functions

protein kinase binding

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPDYE17 as an antibody target. Whether an autoantibody or antibody against SPDYE17 could matter depends on whether native SPDYE17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPDYE17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPDYE17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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