Seroatlas · Human Serome Atlas

SPDYE16

Speedy protein E16

Also known as: SPD16_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NNV3
Gene: SPDYE16
Ensembl: ENSG00000185040
Chromosome: 7
Canonical length: 352 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable protein kinase binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

352 residues, UniProt reviewed canonical sequence.

>A6NNV3|SPDYE16
     1  MDRTETRFRK RGQIKGKITT SRQPHPQNEQ SPQRSTSGYS LQEVVDDEVL GSSAPGVDPS
    61  PPCRSLGWKR KKEWSDESEE EPEKELAPEP EETWVVEMLC GLKMKLKQQR VSPILPEHHK
   121  DFNSQLAPGV DPSPPHRSFC WKRKREWWDE SEESLEEEPR KVLAPEPEEI WVVEMLCGLK
   181  MKLKRRRVSL VLPEHHEAFN RLLEDPVIKR FLAWDKDLRV SDKYLLAMVI AYFSRAGLPS
   241  WQYQRIHFFL ALYLANDMEE DDEDPKQNIF YFLYGKTRSR IPLVRNRRFQ LCRCMNPRAR
   301  KNRSQIALFQ KLRFQFFCSM SGRAWVSREE LEEIQAYDPE HWVWARDRAR LS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPDYE16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 1.1 nTPM

Expression across tissuesHPA

Tissue

testis: 1.1 nTPM
skeletal muscle: 0.6 nTPM
skin: 0.6 nTPM
lymph node: 0.5 nTPM
retina: 0.5 nTPM
bone marrow: 0.4 nTPM

Single-cell type

epicardial cells: 152 nCPM
paneth cells: 35 nCPM
sertoli cells: 18 nCPM
mesothelial cells: 12 nCPM
tuft cells: 12 nCPM
myonuclei: 11 nCPM

Immune cell

neutrophil: 1.5 nTPM
plasmacytoid DC: 1 nTPM
eosinophil: 0.7 nTPM
memory B-cell: 0.7 nTPM
basophil: 0.5 nTPM
memory CD8 T-cell: 0.5 nTPM

Brain region

cerebellum: 5.5 nTPM
thalamus: 5.3 nTPM
white matter: 5.3 nTPM
cerebral cortex: 5.1 nTPM
basal ganglia: 4.8 nTPM
pons: 4.8 nTPM

OntologyGO

Molecular functions

protein kinase binding

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPDYE16 as an antibody target. Whether an autoantibody or antibody against SPDYE16 could matter depends on whether native SPDYE16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPDYE16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPDYE16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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