Seroatlas · Human Serome Atlas

SPDYE12

Speedy protein E12

Also known as: SPD12_HUMAN, SPDYE12P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DUX1
Gene
SPDYE12
Ensembl
ENSG00000184616
Chromosome
7
Canonical length
265 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable protein kinase binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

265 residues, UniProt reviewed canonical sequence.

>P0DUX1|SPDYE12
     1  MGQILGKIMM SHQPQPQEEQ SPQRSTSGYP LQEVVDDEVS GPSAPGVDPS PPRRSLGWKR
    61  KRECLDESDD EPEKELAPEP EETWVAETLC GLKMKAKRRR VSLVLPEYYE AFNRLLEDPV
   121  IKRLLAWDKD LRVSDKYLLA MVIAYFSRAG LPSWQYQRIH FFLALYLAND MEEDDEAPKQ
   181  NIFYFLYEET RSHIPLLREL WFQLCRYMNP RARKNCSQIA LFRKYRFHFF CSMRCRAWVS
   241  LEELEEIQAY DPEHWVWARD RAHLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPDYE12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
1.4 nTPM

Expression across tissuesHPA

Tissue

  • testis: 1.4 nTPM
  • skeletal muscle: 1.1 nTPM
  • cerebral cortex: 0.8 nTPM
  • retina: 0.7 nTPM
  • heart muscle: 0.6 nTPM
  • appendix: 0.5 nTPM

Single-cell type

  • cardiomyocytes: 24 nCPM
  • retinal ganglion cells: 12 nCPM
  • epicardial cells: 11 nCPM
  • myonuclei: 9.7 nCPM
  • retinal bipolar cells: 9.7 nCPM
  • thymocytes: 8.5 nCPM

Immune cell

  • NK-cell: 0.5 nTPM
  • memory CD8 T-cell: 0.4 nTPM
  • MAIT T-cell: 0.3 nTPM
  • memory CD4 T-cell: 0.3 nTPM
  • naive CD8 T-cell: 0.3 nTPM
  • T-reg: 0.3 nTPM

Brain region

  • cerebellum: 6.6 nTPM
  • cerebral cortex: 6.3 nTPM
  • amygdala: 6.1 nTPM
  • hippocampal formation: 6 nTPM
  • basal ganglia: 5.8 nTPM
  • medulla oblongata: 5.5 nTPM

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPDYE12 as an antibody target. Whether an autoantibody or antibody against SPDYE12 could matter depends on whether native SPDYE12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPDYE12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPDYE12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPDYE12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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