Seroatlas · Human Serome Atlas

SPDYE1

Speedy protein E1

Also known as: Ringo1, SPDE1_HUMAN, SPDYE, WBSCR19

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NFV5
Gene: SPDYE1
Ensembl: ENSG00000136206
Chromosome: 7
Canonical length: 336 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

This gene is located at chromosome 7p13 which is close to the Williams Beuren syndrome chromosome region 7q11.23. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

336 residues, UniProt reviewed canonical sequence.

>Q8NFV5|SPDYE1
     1  MQKHYTVAWF LYSAPGVDPS PPCRSLGWKR KREWSDESEE EPEKELAPEP EETWVVETLC
    61  GLKMKLKQQR VSPILLEHHK DFNSQLAPGV DPSPPHRSFC WKRKMEWWDK SEESEEEPRK
   121  VLAPEPEEIW VAEMLCGLKM KLKRRRVSLV LPEHHEAFNR LLEDPVIKRF LAWDKDLRVS
   181  DKYLLAMVIA YFSRAGFPSW QYQRLHFFLA LYLANDMEED DEDSKQNIFH FLYGKNRSRI
   241  PLLRKRRFQL YRSMNPRARK NRSHIPLVRK RRFQLRRCMN PRARKNRSQI VLFQKRRFHF
   301  FCSMSCRAWV SPEELEEIQA YDPEHWVWAR DRARLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPDYE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 6.4 nTPM

Expression across tissuesHPA

Tissue

testis: 6.4 nTPM
bone marrow: 1.4 nTPM
skeletal muscle: 1.3 nTPM
skin: 1.2 nTPM
retina: 0.6 nTPM
appendix: 0.5 nTPM

Single-cell type

epicardial cells: 89 nCPM
early spermatids: 82 nCPM
cardiomyocytes: 69 nCPM
retinal ganglion cells: 58 nCPM
late spermatids: 50 nCPM
myonuclei: 44 nCPM

Immune cell

basophil: 1.9 nTPM
neutrophil: 1.1 nTPM
eosinophil: 0.9 nTPM
naive B-cell: 0.8 nTPM
plasmacytoid DC: 0.8 nTPM
intermediate monocyte: 0.7 nTPM

Brain region

cerebellum: 15 nTPM
cerebral cortex: 15 nTPM
white matter: 14 nTPM
pons: 14 nTPM
thalamus: 14 nTPM
medulla oblongata: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
gnomAD missense Z: -0.46
DepMap mean gene effect: -0.86
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

protein kinase binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Williams-Beuren syndrome

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPDYE1 as an antibody target. Whether an autoantibody or antibody against SPDYE1 could matter depends on whether native SPDYE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPDYE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPDYE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...