Seroatlas · Human Serome Atlas

SPATS2L

SPATS2-like protein

Also known as: DNAPTP6, SGNP, SPS2L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NUQ6
Gene: SPATS2L
Ensembl: ENSG00000196141
Chromosome: 2
Canonical length: 558 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Located in cytosol; nucleolus; and nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

558 residues, UniProt reviewed canonical sequence.

>Q9NUQ6|SPATS2L
     1  MAELNTHVNV KEKIYAVRSV VPNKSNNEIV LVLQQFDFNV DKAVQAFVDG SAIQVLKEWN
    61  MTGKKKNNKR KRSKSKQHQG NKDAKDKVER PEAGPLQPQP PQIQNGPMNG CEKDSSSTDS
   121  ANEKPALIPR EKKISILEEP SKALRGVTEG NRLLQQKLSL DGNPKPIHGT TERSDGLQWS
   181  AEQPCNPSKP KAKTSPVKSN TPAAHLEIKP DELAKKRGPN IEKSVKDLQR CTVSLTRYRV
   241  MIKEEVDSSV KKIKAAFAEL HNCIIDKEVS LMAEMDKVKE EAMEILTARQ KKAEELKRLT
   301  DLASQMAEMQ LAELRAEIKH FVSERKYDEE LGKAARFSCD IEQLKAQIML CGEITHPKNN
   361  YSSRTPCSSL LPLLNAHAAT SGKQSNFSRK SSTHNKPSEG KAANPKMVSS LPSTADPSHQ
   421  TMPANKQNGS SNQRRRFNPQ YHNNRLNGPA KSQGSGNEAE PLGKGNSRHE HRRQPHNGFR
   481  PKNKGGAKNQ EASLGMKTPE APAHSEKPRR RQHAADTSEA RPFRGSVGRV SQCNLCPTRI
   541  EVSTDAAVLS VPAVTLVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATS2L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 156 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 156 nTPM
heart muscle: 110 nTPM
gallbladder: 108 nTPM
liver: 103 nTPM
stomach: 96 nTPM
colon: 80 nTPM

Single-cell type

foveolar cells: 1,144 nCPM
urothelial cells: 907 nCPM
pituitary stem cells: 845 nCPM
colonocytes: 786 nCPM
pituicytes/fscs: 755 nCPM
pancreatic duct cells: 724 nCPM

Immune cell

basophil: 48 nTPM
T-reg: 32 nTPM
myeloid DC: 17 nTPM
MAIT T-cell: 14 nTPM
plasmacytoid DC: 13 nTPM
eosinophil: 7.5 nTPM

Brain region

cerebral cortex: 82 nTPM
midbrain: 77 nTPM
white matter: 75 nTPM
pons: 75 nTPM
choroid plexus: 74 nTPM
spinal cord: 73 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.56
gnomAD missense Z: 1.31
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATS2L as an antibody target. Whether an autoantibody or antibody against SPATS2L could matter depends on whether native SPATS2L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATS2L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATS2L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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