Seroatlas · Human Serome Atlas

SPATS2

Spermatogenesis-associated serine-rich protein 2

Also known as: FLJ13117, SCR59, SPAS2_HUMAN, SPATA10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86XZ4
Gene: SPATS2
Ensembl: ENSG00000123352
Chromosome: 12
Canonical length: 545 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

545 residues, UniProt reviewed canonical sequence.

>Q86XZ4|SPATS2
     1  MSRKQNQKDS SGFIFDLQSN TVLAQGGAFE NMKEKINAVR AIVPNKSNNE IILVLQHFDN
    61  CVDKTVQAFM EGSASEVLKE WTVTGKKKNK KKKNKPKPAA EPSNGIPDSS KSVSIQEEQS
   121  APSSEKGGMN GYHVNGAIND TESVDSLSEG LETLSIDARE LEDPESAMLD TLDRTGSMLQ
   181  NGVSDFETKS LTMHSIHNSQ QPRNAAKSLS RPTTETQFSN MGMEDVPLAT SKKLSSNIEK
   241  SVKDLQRCTV SLARYRVVVK EEMDASIKKM KQAFAELESC LMDREVALLA EMDKVKAEAM
   301  EILLSRQKKA ELLKKMTHVA VQMSEQQLVE LRADIKHFVS ERKYDEDLGR VARFTCDVET
   361  LKKSIDSFGQ VSHPKNSYST RSRCSSVTSV SLSSPSDASA ASSSTCASPP SLTSANKKNF
   421  APGETPAAIA NSSGQPYQPL REVLPGNRRG GQGYRPQGQK SNDPMNQGRH DSMGRYRNSS
   481  WYSSGSRYQS APSQAPGNTI ERGQTHSAGT NGTGVSMEPS PPTPSFKKGL PQRKPRTSQT
   541  EAVNS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

testis: 24 nTPM
parathyroid gland: 20 nTPM
cerebellum: 20 nTPM
salivary gland: 17 nTPM
tonsil: 17 nTPM
skin: 15 nTPM

Single-cell type

plasma cells: 441 nCPM
myonuclei: 394 nCPM
renal connecting tubule cells: 276 nCPM
decidual stromal cells: 212 nCPM
undifferentiated spermatogonia: 201 nCPM
renal collecting duct principal cells: 196 nCPM

Immune cell

plasmacytoid DC: 7.8 nTPM
memory B-cell: 5.9 nTPM
myeloid DC: 4.1 nTPM
naive B-cell: 3.2 nTPM
MAIT T-cell: 1.7 nTPM
gdT-cell: 1.6 nTPM

Brain region

cerebellum: 44 nTPM
cerebral cortex: 39 nTPM
choroid plexus: 35 nTPM
hippocampal formation: 34 nTPM
pons: 34 nTPM
basal ganglia: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.97
gnomAD missense Z: 0.8
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATS2 as an antibody target. Whether an autoantibody or antibody against SPATS2 could matter depends on whether native SPATS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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