Seroatlas · Human Serome Atlas

SPATS1

Spermatogenesis-associated serine-rich protein 1

Also known as: FLJ25442, SPAS1_HUMAN, SPATA8, SRSP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q496A3
Gene: SPATS1
Ensembl: ENSG00000249481
Chromosome: 6
Canonical length: 300 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

No narrative summary is available for SPATS1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

300 residues, UniProt reviewed canonical sequence.

>Q496A3|SPATS1
     1  MSPSMLTGNS PRGCRLPSIS STTCGRQLEK VPEKRDSGMT EVERTYSANC SDFLESKGCF
    61  ANTTPSGKSV SSSSSVETGP SVSEPPGLPR VSAYVDTTAD LDRKLSFSHS DHSSEMSLPE
   121  VQKDKYPEEF SLLKLQTKDG HRPEWTFYPR FSSNIHTYHV GKQCFFNGVF LGNKRSLSER
   181  TVDKCFGRKK YDIDPRNGIP KLTPGDNPYM YPEQSKGFHK AGSMLPPVNF SIVPYEKKFD
   241  TFIPLEPLPQ IPNLPFWVKE KANSLKNEIQ EVEELDNWQP AVPLMHMLHL SGALDFPRQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

testis: 21 nTPM
fallopian tube: 7.2 nTPM
epididymis: 5.5 nTPM
choroid plexus: 1 nTPM
basal ganglia: 0.7 nTPM
hippocampal formation: 0.7 nTPM

Single-cell type

late spermatids: 26 nCPM
early spermatids: 25 nCPM
late primary spermatocytes: 23 nCPM
ependymal cells: 11 nCPM
respiratory ciliated cells: 7.2 nCPM
epididymal efferent duct ciliated cells: 4.2 nCPM

Immune cell

neutrophil: 0.3 nTPM
basophil: 0.2 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM
naive B-cell: 0.1 nTPM
NK-cell: 0.1 nTPM

Brain region

midbrain: 4.6 nTPM
medulla oblongata: 3.4 nTPM
white matter: 3.1 nTPM
spinal cord: 3 nTPM
hippocampal formation: 1.8 nTPM
hypothalamus: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.26
gnomAD pLI: 0
gnomAD missense Z: 0.84
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Spermatogenesis-associated serine-rich protein 1
Spermatogenesis-associated serine-rich protein 1

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATS1 as an antibody target. Whether an autoantibody or antibody against SPATS1 could matter depends on whether native SPATS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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