Seroatlas · Human Serome Atlas

SPATC1L

Speriolin-like protein

Also known as: C21orf56, SPC1L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0A9
Gene: SPATC1L
Ensembl: ENSG00000160284
Chromosome: 21
Canonical length: 340 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in spermatogenesis. Predicted to act upstream of or within actin polymerization or depolymerization; positive regulation of cAMP-dependent protein kinase activity; and positive regulation of cAMP/PKA signal transduction. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

340 residues, UniProt reviewed canonical sequence.

>Q9H0A9|SPATC1L
     1  MAEGGELMSR LLSENADLKK QVRLLKENQM LRRLLSQSCQ EGGGHDLLPP RAHAYPEAGS
    61  PGSGVPDFGR FTSVADTPSQ LQTSSLEDLL CSHAPLSSED DTSPGCAAPS QAPFKAFLSP
   121  PEPHSHRGTD RKLSPLLSPL QDSLVDKTLL EPREMVRPKK VCFSESSLPT GDRTRRSYYL
   181  NEIQSFAGAE KDARVVGEIA FQLDRRILAY VFPGVTRLYG FTVANIPEKI EQTSTKSLDG
   241  SVDERKLREL TQRYLALSAR LEKLGYSRDV HPAFSEFLIN TYGILKQRPD LRANPLHSSP
   301  AALRKLVIDV VPPKFLGDSL LLLNCLCELS KEDGKPLFAW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATC1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

testis: 47 nTPM
prostate: 31 nTPM
amygdala: 24 nTPM
hippocampal formation: 22 nTPM
adrenal gland: 22 nTPM
basal ganglia: 20 nTPM

Single-cell type

other brain neurons: 12 nCPM
brain excitatory neurons: 8.5 nCPM
brain inhibitory neurons: 8.1 nCPM
oligodendrocytes: 8.1 nCPM
oligodendrocyte progenitor cells: 7.6 nCPM
late spermatids: 5.6 nCPM

Immune cell

eosinophil: 36 nTPM
naive CD4 T-cell: 9.7 nTPM
naive CD8 T-cell: 9.2 nTPM
myeloid DC: 8.7 nTPM
memory B-cell: 7.6 nTPM
naive B-cell: 7.6 nTPM

Brain region

amygdala: 18 nTPM
basal ganglia: 16 nTPM
hippocampal formation: 15 nTPM
cerebral cortex: 14 nTPM
hypothalamus: 11 nTPM
midbrain: 9.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.81
gnomAD pLI: 0
gnomAD missense Z: 0.29
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATC1L as an antibody target. Whether an autoantibody or antibody against SPATC1L could matter depends on whether native SPATC1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATC1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATC1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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