Seroatlas · Human Serome Atlas

SPATA9

Spermatogenesis-associated protein 9

Also known as: FLJ35906, NYD-SP16, SPAT9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BWV2
Gene: SPATA9
Ensembl: ENSG00000145757
Chromosome: 5
Canonical length: 254 aa
Protein class: Predicted membrane proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

254 residues, UniProt reviewed canonical sequence.

>Q9BWV2|SPATA9
     1  MPIKPVGWIC GQVLKNFSGR IEGIQKAIMD LVDEFKDEFP TILRLSQSNQ KREPAQKTSK
    61  IRMAIALAKI NRATLIRGLN SISRSSKSVA KLLHPQLACR LLELRDISGR LLREVNAPRQ
   121  PLYNIQVRKG SLFEIISFPA KTALTSIIYA SYAALIYLAV CVNAVLKKVK NIFQEEESIR
   181  QNREESENCR KAFSEPVLSE PMFAEGEIKA KPYRSLPEKP DISDYPKLLA NKQSNNIQVL
   241  HSVFDQSAEM NEQI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

testis: 23 nTPM
adipose tissue: 1 nTPM
ovary: 0.5 nTPM
breast: 0.4 nTPM
skin: 0.4 nTPM
adrenal gland: 0.3 nTPM

Single-cell type

late spermatids: 730 nCPM
early spermatids: 599 nCPM
late primary spermatocytes: 325 nCPM
adipocytes: 112 nCPM
extravillous trophoblasts: 72 nCPM
cardiomyocytes: 28 nCPM

Immune cell

eosinophil: 0.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 1.3 nTPM
cerebellum: 0.7 nTPM
cerebral cortex: 0.5 nTPM
hypothalamus: 0.5 nTPM
basal ganglia: 0.4 nTPM
choroid plexus: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0
gnomAD missense Z: 0.67
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Spermatogenesis-associated protein 9
Spermatogenesis-associated protein 9

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA9 as an antibody target. Whether an autoantibody or antibody against SPATA9 could matter depends on whether native SPATA9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATA9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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