Seroatlas · Human Serome Atlas

SPATA6L

Spermatogenesis associated 6-like protein

Also known as: C9orf68, FLJ10058, SPA6L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N4H0
Gene: SPATA6L
Ensembl: ENSG00000106686
Chromosome: 9
Canonical length: 392 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable myosin light chain binding activity. Predicted to be involved in spermatogenesis. Predicted to be located in sperm head-tail coupling apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

392 residues, UniProt reviewed canonical sequence.

>Q8N4H0|SPATA6L
     1  MPLEVVVELQ IRAISCPGVF LPGKQDVYLG VYLMNQYLET NSFPSAFPIM IQESMRFEKV
    61  FESAVDPGAV VDLLEMWDEL AYYEENTRDF LFPEPKLTPS HPRRCREVLM KTALGFPGIA
   121  PKIEFSTRTA IRECVFLHRN RFLEERHESR RPLSTSHEPI FPLNTIKMKL KENNLNRLPK
   181  GMQARAPSQY STRHFFQDQP AQLNLGNNFK ISGGSKPPFV VRHVDSAKPF GENISEHHLR
   241  RSRRKSKFSD FPFPTRRASS LDSLAANVKV IKEPDERIVL RSDSSSCLDS SQFGKSSSSK
   301  QGDADFHGKA SFATYQHSTS PGPLDQPLLR ERFHPGSQST WKNIHERVCS LLTSHRAQLH
   361  QNKEDSTSEV NYIIERPSYP LKKYSLHEQR YF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA6L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 5.3 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 5.3 nTPM
testis: 4.9 nTPM
fallopian tube: 4.8 nTPM
liver: 3.6 nTPM
stomach: 2.5 nTPM
small intestine: 2.3 nTPM

Single-cell type

ependymal cells: 430 nCPM
respiratory ciliated cells: 400 nCPM
somatotrophs: 290 nCPM
lactotrophs: 270 nCPM
fallopian tube ciliated cells: 242 nCPM
thyrotrophs: 229 nCPM

Immune cell

naive CD8 T-cell: 0.4 nTPM
naive CD4 T-cell: 0.3 nTPM
gdT-cell: 0.2 nTPM
MAIT T-cell: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM

Brain region

choroid plexus: 13 nTPM
cerebellum: 11 nTPM
midbrain: 11 nTPM
medulla oblongata: 9.6 nTPM
hypothalamus: 9 nTPM
spinal cord: 7.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.74
gnomAD pLI: 0
gnomAD missense Z: -2.46
DepMap mean gene effect: 0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA6L as an antibody target. Whether an autoantibody or antibody against SPATA6L could matter depends on whether native SPATA6L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA6L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATA6L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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