Seroatlas · Human Serome Atlas

SPATA46

Spermatogenesis-associated protein 46

Also known as: C1orf111, SPT46_HUMAN, TEKT2BP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T0L3
Gene: SPATA46
Ensembl: ENSG00000171722
Chromosome: 1
Canonical length: 261 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in fusion of sperm to egg plasma membrane involved in single fertilization and spermatogenesis. Predicted to be located in membrane and nucleus. Predicted to be active in nuclear membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

261 residues, UniProt reviewed canonical sequence.

>Q5T0L3|SPATA46
     1  MENFSLLSIS GPPISSSALS AFPDIMFSRA TSLPDIAKTA VPTEASSPAQ ALPPQYQSII
    61  VRQGIQNTAL SPDCSLGDTQ HGEKLRRNCT IYRPWFSPYS YFVCADKESQ LEAYDFPEVQ
   121  QDEGKWDNCL SEDMAENICS SSSSPENTCP REATKKSRHG LDSITSQDIL MASRWHPAQQ
   181  NGYKCVACCR MYPTLDFLKS HIKRGFREGF SCKVYYRKLK ALWSKEQKAR LGDRLSSGSC
   241  QAFNSPAEHL RQIGGEAYLC L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA46 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

testis: 30 nTPM
adrenal gland: 3 nTPM
retina: 2.2 nTPM
pituitary gland: 0.6 nTPM
cerebellum: 0.4 nTPM
liver: 0.3 nTPM

Single-cell type

early spermatids: 819 nCPM
late primary spermatocytes: 376 nCPM
late spermatids: 240 nCPM
epicardial cells: 9.1 nCPM
cone photoreceptor cells: 6.2 nCPM
sertoli cells: 6.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 5.7 nTPM
hippocampal formation: 3.9 nTPM
basal ganglia: 3.6 nTPM
cerebral cortex: 3.6 nTPM
medulla oblongata: 3.4 nTPM
cerebellum: 3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

nuclear membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPATA46 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HLCS

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA46 as an antibody target. Whether an autoantibody or antibody against SPATA46 could matter depends on whether native SPATA46 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA46 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATA46 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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