Seroatlas · Human Serome Atlas

SPATA45

Spermatogenesis-associated protein 45

Also known as: C1orf227, LOC149643, SPT45_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q537H7
Gene
SPATA45
Ensembl
ENSG00000185523
Chromosome
1
Canonical length
98 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles,Cytosol

OverviewNCBI Gene

No narrative summary is available for SPATA45 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

98 residues, UniProt reviewed canonical sequence.

>Q537H7|SPATA45
     1  MASINRTIEI MKKHGVSKQH LLEEINKKRE SNCLVERSNQ VSLLRVQKRH FPDAYQSFTD
    61  TTTKEPVPNS GRSSWIKLSL LAHMERKHFP PKNNAIFG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA45 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • testis: 12 nTPM
  • pancreas: 2.8 nTPM
  • epididymis: 0.7 nTPM
  • fallopian tube: 0.7 nTPM
  • lymph node: 0.7 nTPM
  • retina: 0.5 nTPM

Single-cell type

  • late spermatids: 187 nCPM
  • early spermatids: 162 nCPM
  • late primary spermatocytes: 70 nCPM
  • retinal pigment epithelial cells: 21 nCPM
  • oligodendrocytes: 3.3 nCPM
  • early primary spermatocytes: 3 nCPM

Immune cell

  • eosinophil: 1.6 nTPM
  • naive B-cell: 1.1 nTPM
  • neutrophil: 0.9 nTPM
  • intermediate monocyte: 0.3 nTPM
  • MAIT T-cell: 0.3 nTPM
  • naive CD8 T-cell: 0.3 nTPM

Brain region

  • medulla oblongata: 2.2 nTPM
  • white matter: 2.1 nTPM
  • thalamus: 2 nTPM
  • spinal cord: 1.9 nTPM
  • pons: 1.8 nTPM
  • basal ganglia: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.54
gnomAD pLI
0.2
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Spermatogenesis-associated protein 45, mammals

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA45 as an antibody target. Whether an autoantibody or antibody against SPATA45 could matter depends on whether native SPATA45 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA45 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATA45 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPATA45. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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