Seroatlas · Human Serome Atlas

SPATA31J1

Putative protein SPATA31J1

Also known as: S31J1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NFR6
Gene: SPATA31J1
Canonical length: 353 aa

OverviewNCBI Gene

No narrative summary is available for SPATA31J1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

353 residues, UniProt reviewed canonical sequence.

>A6NFR6|SPATA31J1
     1  MPRAQLPEDS SAVDMDILFP LDSVIGTELC PSPIPQIIHF VLFVVFSLVI LIILRLYIPR
    61  EPSSVPPREE DSENDQAEVG EWLRIGNKYI TLKDYRILLK ELENLEIYTF LSKKCLKKLS
   121  REGSSHHLPR QVRPGPVYKP APARNHRPRG GRGKASPTSF HVSPRAPLAP LASMPSSVPK
   181  TSVESLGSPS SLSSSKPREP LCPLKHPSHQ PPASTLSPNP TSSTESLGYL SSLSSSQPPE
   241  PLRPLKHPSH KPRGRSLPRR RNPGWVSWSD SMQADSETDT IICPMCKAPE RSCPHTWWVP
   301  SSPRVIRGVG RCSDPNLGLS WRQEAARAWC HCTSSQFPFK HPNLPTHLPK ASF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA31J1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.66

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA31J1 as an antibody target. Whether an autoantibody or antibody against SPATA31J1 could matter depends on whether native SPATA31J1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA31J1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATA31J1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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