Seroatlas · Human Serome Atlas

SPATA31H1

Spermatogenesis-associated protein 31H1

Also known as: S31H1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q68DN1
Gene: SPATA31H1
Canonical length: 1984 aa

OverviewNCBI Gene

No narrative summary is available for SPATA31H1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1984 residues, UniProt reviewed canonical sequence.

>Q68DN1|SPATA31H1
     1  MELTPGAQQQ GINYQELTSG WQDVKSMMLV PEPTRKFPSG PLLTSVRFSN LSPESQQQDV
    61  KSLEFTVEPK LQSVKHVKLS SVSLQQTIKS VELAPGSLPQ RVKYGEQTPR TNYQIMESSE
   121  LIPRPGHQFA KYAEMIPQPK YQIPKSANLI SIPIYHATES SEMAQGLAYK GIDTVEKSVG
   181  LTPKLTGRAK ESLGMLLQPD LQVPKFVDLT PMVRDQGSKF LGLTPEKSYQ ILETMELLSQ
   241  SRPRVKDVGE LYMKPLQQTV EYEGITPELK HYFTEAMGLT AEARIQANEF FGMTPKPTSQ
   301  ATGFAERSPR LCPQNLECVE VISEKRLQGE ESVVLIPKSL HHVPDSASGM TPGLGHRVPE
   361  SVELTSKSGV QVEKTLQLTP KPQHHVGSPG IISGLGHQVP ESVNLTCKQW LQMEESLEVP
   421  LKQTSQVIGH EESVELTSEA RQHREVSMGL TKSKNQSMKS PGTTPGPLGR IVEFMRISPE
   481  PLDQVTESAR TQLQVAQSEE VILIDVPKVV QSVKVTPGPP FQIVKSVTIP RPTPQMVEYI
   541  ELTPKLQYVR PSEHHTGPCL QDVKSTKLIT KPKHQILETV ELTGFQIVKT MLIPGPSLQI
   601  VKSEELAPGP IPQVVEPIGV ALESGIEAIN CVDLLPRPHL QELIVPAELT PSPCTQVKSA
   661  ELTSPQTSPF EEHTILTHKQ GLQAVKSTVI KTEPPKVMET EDLNLGHVCQ NRDCQKLTSE
   721  ELQVGTDFSR FLQSSSTTLI SSSVRTASEL GGLWDSGIQE VSRALDIKNP GTDILQPEET
   781  YIDPTMIQSL TFPLALHNQS SDKTANIVEN PCPEILGVDV ISKETTKRKQ MEELENSLQR
   841  HLPQSWRSRS RTFQAESGVQ KGLIKSFPGR QHNVWESHAW RQRLPRKYLS TMLMLGNILG
   901  TTMERKLCSQ TSLAERATAD TCQSIQNLFG IPAELMEPSQ SLPEKGPVTI SQPSVVKNYI
   961  QRHTFYHGHK KRMALRIWTR GSTSSIIQQY SGTRVRIKKT NSTFNGISQE VIQHMPVSCA
  1021  GGQLPVLVKS ESSLSIFYDR EDLVPMEESE DSQSDSQTRI SESQHSLKPN YLSQAKTDFS
  1081  EQFQLLEDLQ LKIAAKLLRS QIPPDVPPPL ASGLVLKYPI CLQCGRCSGL NCHHKLQTTS
  1141  GPYLLIYPQL HLVRTPEGHG EVRLHLGFRL RIGKRSQISK YRERDRPVIR RSPISPSQRK
  1201  AKIYTQASKS PTSTIDLQSG PSQSPAPVQV YIRRGQRSRP DLVEKTKTRA PGHYEFTQVH
  1261  NLPESDSEST QNEKRAKVRT KKTSDSKYPM KRITKRLRKH RKFYTNSRTT IESPSRELAA
  1321  HLRRKRIGAT QTSTASLKRQ PKKPSQPKFM QLLFQSLKRA FQTAHRVIAS VGRKPVDGTR
  1381  PDNLWASKNY YPKQNARDYC LPSSIKRDKR SADKLTPAGS TIKQEDILWG GTVQCRSAQQ
  1441  PRRAYSFQPR PLRLPKPTDS QSGIAFQTAS VGQPLRTVQK DSSSRSKKNF YRNETSSQES
  1501  KNLSTPGTRV QARGRILPGS PVKRTWHRHL KDKLTHKEHN HPSFYRERTP RGPSERTRHN
  1561  PSWRNHRSPS ERSQRSSLER RHHSPSQRSH CSPSRKNHSS PSERSWRSPS QRNHCSPPER
  1621  SCHSLSERGL HSPSQRSHRG PSQRRHHSPS ERSHRSPSER SHRSSSERRH RSPSQRSHRG
  1681  PSERSHCSPS ERRHRSPSQR SHRGPSERRH HSPSKRSHRS PARRSHRSPS ERSHHSPSER
  1741  SHHSPSERRH HSPSERSHCS PSERSHCSPS ERRHRSPSER RHHSPSEKSH HSPSERSHHS
  1801  PSERRRHSPL ERSRHSLLER SHRSPSERRS HRSFERSHRR ISERSHSPSE KSHLSPLERS
  1861  RCSPSERRGH SSSGKTCHSP SERSHRSPSG MRQGRTSERS HRSSCERTRH SPSEMRPGRP
  1921  SGRNHCSPSE RSRRSPLKEG LKYSFPGERP SHSLSRDFKN QTTLLGTTHK NPKAGQVWRP
  1981  EATR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA31H1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SPATA31H1.

Disease | ImmuneIEDB

Conditions an epitope on SPATA31H1 was assayed in.

hepatocellular carcinoma T cell

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

KeywordsUniProt

Repeat

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA31H1 as an antibody target. Whether an autoantibody or antibody against SPATA31H1 could matter depends on whether native SPATA31H1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA31H1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATA31H1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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