Seroatlas · Human Serome Atlas

SPATA31G1

Spermatogenesis-associated protein 31G1

Also known as: C9orf131, MGC41945, S31G1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VYM1
Gene: SPATA31G1
Ensembl: ENSG00000174038
Chromosome: 9
Canonical length: 1079 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

No narrative summary is available for SPATA31G1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1079 residues, UniProt reviewed canonical sequence.

>Q5VYM1|SPATA31G1
     1  MEWLLEDLLG AKGDMGLLWG QLTHALACRH CGSSCFQSPG NLVTLFLFVV WQIQRWWQLG
    61  RLRQLHPWCS GNMVQGKELP LLHRVAFLDH LCKQKSEVEE EGEEEEEGED EASLDPLKPC
   121  SPTKEAPTGE QATPAPPQPS CGSEGLLKAI GIPEQTVMQP VSPSRSFPIF QILTSFPVRH
   181  KIASGNRQQQ RKSQLFWGLP SLHSESLEAI FLSSGGPSPL KWSVCSSVFF NKLAFLPRSN
   241  LLLPQYHSSA QFSTHGAHTM EDLEGMAPDP QLLPPPSSPS VSSLLLHLRP FPVDHKGVLS
   301  GAEAPTQSPG TSPLEVLPGY ETHLETTGHK KMPQAFEPPM PPPCQSPASL SEPRKVSPEG
   361  GLAISKDFWG TVGYREKPQA SESSMPVPCP PLDSLPELQR ESSLEDPSRY KPQWECRENS
   421  GNLWAFESPV LDLNPELSGT SPECVPPASE TPWKGMQSRE NIWVPADPVS PPSLPSVPLL
   481  ESLVMGPQGV LSESKALWET MGQKENLWAS DSPDPVHSTP PTTLMEPHRI NPGECLATSE
   541  ATWKDTEHSR NSSASRSPSL ALSPPPALAP ELLRVRSMGV LSDSEARCGD IQKTKNSWAS
   601  KHPACNLPQD LHGASPLGVL SDSQSIVGEM EQKENCVPVF PGRGSSPSSN SVSKSHVSEP
   661  IADQSNYKPD GEAVEQRKNH WATELPAPSS LSTPLPEPHI DLELVWRNVQ QREVPQGPSP
   721  LAVDPLHPVP QPPTLAEAVK IERTHPGLPK GVTCPGVKAE APLSQRWTVP ELLTHPGIHA
   781  WQWSRELKLR LKKLRQSPAS RAPGPSQSFC SSPILSSTIP DFWGLPSCPP QQIYPPNPCP
   841  HSSSCHPQEV QRTVPQPVQS SHCHHFQSSS QLQPQESGRA EQGSQRGEKM KGKMVSQVPS
   901  QGPCVHMEAG VDYLSPGPGE PSNSKVLVSG KRKDKASASS SAKKREHPRK PKAGDHRRGT
   961  ARLGLSTVTG KNHPAQARSL VEAPVSTFPQ RSQHRGQSSQ HTALPQLLLP KASGPQDQPE
  1021  AGRRASDILT PRHCKHCPWA HMEKYLSFPT LKASLTRGLQ KVLAKCLDNH RPLPTKSSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA31G1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

testis: 34 nTPM
bone marrow: 2.5 nTPM
endometrium: 2.5 nTPM
gallbladder: 1.9 nTPM
retina: 1.3 nTPM
cervix: 1.2 nTPM

Single-cell type

early spermatids: 129 nCPM
epicardial cells: 109 nCPM
late primary spermatocytes: 74 nCPM
late spermatids: 47 nCPM
cardiomyocytes: 30 nCPM
myonuclei: 8.7 nCPM

Immune cell

basophil: 0.5 nTPM
memory CD8 T-cell: 0.3 nTPM
neutrophil: 0.3 nTPM
naive B-cell: 0.2 nTPM
NK-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM

Brain region

cerebellum: 41 nTPM
cerebral cortex: 32 nTPM
white matter: 31 nTPM
hypothalamus: 29 nTPM
thalamus: 28 nTPM
basal ganglia: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Spermatogenesis-associated protein 31G1-like

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA31G1 as an antibody target. Whether an autoantibody or antibody against SPATA31G1 could matter depends on whether native SPATA31G1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA31G1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATA31G1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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