Seroatlas · Human Serome Atlas

SPATA31F3

Protein SPATA31F3

Also known as: FAM205C, FAM205CP, S31F3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NFA0
Gene
SPATA31F3
Ensembl
ENSG00000187791
Chromosome
9
Canonical length
338 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

338 residues, UniProt reviewed canonical sequence.

>A6NFA0|SPATA31F3
     1  MLSPTFVLWD VGYPLYTYGS ICIIALIIWQ VKKSCQKLSL VPNRSCCRCH RRVQQKSGDR
    61  TSRARRTSQE EAEKLWKLLF LMKSQGWLPQ EGSVRRILCA DPCCQICNVM ALEIKQLLAG
   121  ENNQISLTSL GPSQGSSCLE ALSTSSVSFK HSQDLGSPKS KELSLASVTP TLSQLMDQKS
   181  LTQSAARSAG ADSVQDSWAD HFQRGQRSQV PAVSQVMGSL SSNFEKPGIP LSQQERTKNN
   241  SKFVLENQEA PEVGLDNKMK LFLHWINPEM KDRRHEESIL LSKAETVTQD RTKNIEKSPT
   301  VTKDHVWGAT TQKTTEDPEA QPPSTEEEGL IFCDAPSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA31F3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • testis: 28 nTPM
  • kidney: 0.7 nTPM
  • retina: 0.6 nTPM
  • lymph node: 0.4 nTPM
  • skeletal muscle: 0.3 nTPM
  • skin: 0.3 nTPM

Single-cell type

  • late spermatids: 635 nCPM
  • early spermatids: 386 nCPM
  • oocytes: 41 nCPM
  • late primary spermatocytes: 21 nCPM
  • sertoli cells: 3.4 nCPM
  • epicardial cells: 2.3 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 1.6 nTPM
  • hypothalamus: 1.6 nTPM
  • white matter: 1.6 nTPM
  • hippocampal formation: 1.5 nTPM
  • medulla oblongata: 1.5 nTPM
  • midbrain: 1.5 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA31F3 as an antibody target. Whether an autoantibody or antibody against SPATA31F3 could matter depends on whether native SPATA31F3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA31F3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATA31F3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPATA31F3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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