Seroatlas · Human Serome Atlas

SPATA2L

Spermatogenesis-associated protein 2-like protein

Also known as: C16orf76, MGC26885, SPA2L_HUMAN, tamo

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IUW3
Gene: SPATA2L
Ensembl: ENSG00000158792
Chromosome: 16
Canonical length: 424 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria,Cytosol

OverviewNCBI Gene

Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

424 residues, UniProt reviewed canonical sequence.

>Q8IUW3|SPATA2L
     1  MGSSSLSEDY RQCLERELRR GRAGVCGDPS LRAVLWQILV EDFDLHGALQ DDALALLTDG
    61  LWGRADLAPA LRGLARAFEL LELAAVHLYL LPWRKEFTTI KTFSGGYVHV LKGVLSDDLL
   121  LKSFQKMGYV RRDSHRLMVT ALPPACQLVQ VALGCFALRL ECEILGEVLA QLGTSVLPAE
   181  ELLQARRASG DVASCVAWLQ QRLAQDEEPP PLPPRGSPAA YRAPLDLYRD LQEDEGSEDA
   241  SLYGEPSPGP DSPPAELAYR PPLWEQSAKL WGTGGRAWEP PAEELPQASS PPYGALEEGL
   301  EPEPSAFSFL SLRRELSRPG DLATPESSAA ASPRRIRAEG VPASAYRSVS EPPGYQAHSC
   361  LSPGALPTLC CDTCRQLHAA HCAALPACRP GHSLRVLLGD AQRRLWLQRA QMDTLLYNSP
   421  GARP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA2L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 16 nTPM
pancreas: 14 nTPM
liver: 13 nTPM
cerebral cortex: 13 nTPM
basal ganglia: 12 nTPM
hippocampal formation: 9.8 nTPM

Single-cell type

neutrophils: 57 nCPM
enterocytes: 50 nCPM
syncytiotrophoblasts: 38 nCPM
rod photoreceptor cells: 32 nCPM
colonocytes: 32 nCPM
fallopian secretory cells: 31 nCPM

Immune cell

neutrophil: 14 nTPM
intermediate monocyte: 6.5 nTPM
gdT-cell: 5.5 nTPM
eosinophil: 5.3 nTPM
non-classical monocyte: 4.9 nTPM
plasmacytoid DC: 4.6 nTPM

Brain region

cerebral cortex: 20 nTPM
hippocampal formation: 18 nTPM
basal ganglia: 15 nTPM
white matter: 15 nTPM
amygdala: 14 nTPM
choroid plexus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0.04
gnomAD missense Z: -0.26
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of SPATA2L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

GRB2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA2L as an antibody target. Whether an autoantibody or antibody against SPATA2L could matter depends on whether native SPATA2L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA2L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATA2L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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