Seroatlas · Human Serome Atlas

SPATA19

Spermatogenesis-associated protein 19, mitochondrial

Also known as: CT132, FLJ25851, SPAS1, spergen1, SPT19_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z5L4
Gene: SPATA19
Ensembl: ENSG00000166118
Chromosome: 11
Canonical length: 167 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in sperm mitochondrion organization. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

167 residues, UniProt reviewed canonical sequence.

>Q7Z5L4|SPATA19
     1  MIITTWIVYI LARKGVGLPF LPITSSDIDV VESEAVSVLH HWLKKTEEEA SRGIKEKLSI
    61  NHPSQGVREK MSTDSPPTHG QDIHVTRDVV KHHLSKSDLL ANQSQEVLEE RTRIQFIRWS
   121  HTRIFQVPSE MTEDIMRDRI EQVRRSISRL TDVSAQDFSM RPSSSDC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 125 nTPM

Expression across tissuesHPA

Tissue

testis: 125 nTPM
choroid plexus: 0.2 nTPM
esophagus: 0.2 nTPM
heart muscle: 0.2 nTPM
basal ganglia: 0.1 nTPM
cerebellum: 0.1 nTPM

Single-cell type

late spermatids: 3,140 nCPM
early spermatids: 938 nCPM
late primary spermatocytes: 169 nCPM
sertoli cells: 11 nCPM
undifferentiated spermatogonia: 3.3 nCPM
leydig cells: 2.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.5 nTPM
white matter: 0.4 nTPM
basal ganglia: 0.3 nTPM
cerebellum: 0.3 nTPM
hippocampal formation: 0.3 nTPM
midbrain: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0
gnomAD missense Z: -0.28
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Spermatogenesis-associated protein 19, mitochondrial
Spermatogenesis-associated protein 19, mitochondrial

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA19 as an antibody target. Whether an autoantibody or antibody against SPATA19 could matter depends on whether native SPATA19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATA19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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