Seroatlas · Human Serome Atlas

SPATA16

Spermatogenesis-associated protein 16

Also known as: NYD-SP12, SPT16_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXB7
Gene: SPATA16
Ensembl: ENSG00000144962
Chromosome: 3
Canonical length: 569 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a testis-specific protein that belongs to the tetratricopeptide repeat-like superfamily. The encoded protein localizes to the Golgi apparatus and may play a role in spermatogenesis. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

569 residues, UniProt reviewed canonical sequence.

>Q9BXB7|SPATA16
     1  MDAGSSRSLE NAVNRIYHDQ LVPKINTSKK MSTLAHPPNI LEMSQEIKKN CGGKQVEITL
    61  ERTKMTKGIK EKQSNDLEKA AFKRKAEGEE KPTRKKQAKI TELDNQLITM PLPHIPLKNI
   121  MDVEMKLVYI DEMGVRYEFV ESFMSTGSQP TCQAAEIVDP LSVHNFSFLP QIDKWLQVAL
   181  KDASSCYRQK KYALAAGQFR TALELCSKGA VLGEPFDAPA EDIASVASFI ETKLVTCYLR
   241  MRKPDLALNH AHRSIVLNPA YFRNHLRQAT VFRCLERYSE AARSAMIADY MFWLGGGREE
   301  SISKLIKLYW QAMIEEAITR AESFSVMYTP FATKIRADKI EKVKDAFTKT HPAYAEYMYT
   361  DLQALHMLPQ TVDWSSFPPQ QYLLTLGFKN KDDGKFLEKI SSRKLPIFTE HKTPFGLTRE
   421  DTVRQMETMG KRILPILDFI RSTQLNGSFP ASSGVMEKLQ YASLLSQLQR VKEQSQVINQ
   481  AMAELATIPY LQDISQQEAE LLQSLMADAM DTLEGRRNNN ERVWNMIQKV GQIEDFLYQL
   541  EDSFLKTKKL RTARRQKTKM KRLQTVQQR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 56 nTPM

Expression across tissuesHPA

Tissue

testis: 56 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

late primary spermatocytes: 592 nCPM
early spermatids: 247 nCPM
late spermatids: 180 nCPM
platelets: 47 nCPM
oocytes: 9.2 nCPM
early primary spermatocytes: 7.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SPATA16.

Disease | AllUniProt

Conditions SPATA16 is implicated in, by any mechanism.

Spermatogenic failure 6 (SPGF6) MIM:102530

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0
gnomAD missense Z: 0.2
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Tetratricopeptide-like helical domain superfamily
Spermatogenesis-associated protein 16
Spermatogenesis-associated, N-terminal

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA16 as an antibody target. Whether an autoantibody or antibody against SPATA16 could matter depends on whether native SPATA16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATA16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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