Seroatlas · Human Serome Atlas

SPARCL1

SPARC-like protein 1

Also known as: MAST9, SPRL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14515
Gene
SPARCL1
Ensembl
ENSG00000152583
Chromosome
4
Canonical length
664 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, Transporters
Secretome location
Secreted in other tissues

OverviewNCBI Gene

Predicted to enable calcium ion binding activity; collagen binding activity; and extracellular matrix binding activity. Predicted to be involved in regulation of synapse organization. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

664 residues, UniProt reviewed canonical sequence.

>Q14515|SPARCL1
     1  MKTGLFFLCL LGTAAAIPTN ARLLSDHSKP TAETVAPDNT AIPSLRAEAE ENEKETAVST
    61  EDDSHHKAEK SSVLKSKEES HEQSAEQGKS SSQELGLKDQ EDSDGHLSVN LEYAPTEGTL
   121  DIKEDMSEPQ EKKLSENTDF LAPGVSSFTD SNQQESITKR EENQEQPRNY SHHQLNRSSK
   181  HSQGLRDQGN QEQDPNISNG EEEEEKEPGE VGTHNDNQER KTELPREHAN SKQEEDNTQS
   241  DDILEESDQP TQVSKMQEDE FDQGNQEQED NSNAEMEEEN ASNVNKHIQE TEWQSQEGKT
   301  GLEAISNHKE TEEKTVSEAL LMEPTDDGNT TPRNHGVDDD GDDDGDDGGT DGPRHSASDD
   361  YFIPSQAFLE AERAQSIAYH LKIEEQREKV HENENIGTTE PGEHQEAKKA ENSSNEEETS
   421  SEGNMRVHAV DSCMSFQCKR GHICKADQQG KPHCVCQDPV TCPPTKPLDQ VCGTDNQTYA
   481  SSCHLFATKC RLEGTKKGHQ LQLDYFGACK SIPTCTDFEV IQFPLRMRDW LKNILMQLYE
   541  ANSEHAGYLN EKQRNKVKKI YLDEKRLLAG DHPIDLLLRD FKKNYHMYVY PVHWQFSELD
   601  QHPMDRVLTH SELAPLRASL VPMEHCITRF FEECDPNKDK HITLKEWGHC FGIKEEDIDE
   661  NLLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPARCL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
1,754 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 1,754 nTPM
  • basal ganglia: 1,304 nTPM
  • cerebral cortex: 1,190 nTPM
  • smooth muscle: 1,113 nTPM
  • endometrium: 1,070 nTPM
  • amygdala: 1,016 nTPM

Single-cell type

  • vascular smooth muscle cells: 4,427 nCPM
  • vascular endothelial cells: 3,262 nCPM
  • decidual stromal cells: 2,654 nCPM
  • pericytes: 2,486 nCPM
  • peritubular myoid cells: 2,438 nCPM
  • smooth muscle cells: 1,882 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 1,055 nTPM
  • basal ganglia: 904 nTPM
  • spinal cord: 842 nTPM
  • midbrain: 762 nTPM
  • hypothalamus: 740 nTPM
  • hippocampal formation: 629 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SPARCL1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 117 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Stromal corneal dystrophy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.97
gnomAD pLI
0
gnomAD missense Z
0.06
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPARCL1 as an antibody target. Whether an autoantibody or antibody against SPARCL1 could matter depends on whether native SPARCL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPARCL1 is annotated as secreted, so native SPARCL1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SPARCL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPARCL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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