Seroatlas · Human Serome Atlas

SPARC

SPARC

Also known as: BM-40, ON, ONT, SPRC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P09486
Gene
SPARC
Ensembl
ENSG00000113140
Chromosome
5
Canonical length
303 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Vesicles
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015]

Canonical amino-acid sequenceUniProt

303 residues, UniProt reviewed canonical sequence.

>P09486|SPARC
     1  MRAWIFFLLC LAGRALAAPQ QEALPDETEV VEETVAEVTE VSVGANPVQV EVGEFDDGAE
    61  ETEEEVVAEN PCQNHHCKHG KVCELDENNT PMCVCQDPTS CPAPIGEFEK VCSNDNKTFD
   121  SSCHFFATKC TLEGTKKGHK LHLDYIGPCK YIPPCLDSEL TEFPLRMRDW LKNVLVTLYE
   181  RDEDNNLLTE KQKLRVKKIH ENEKRLEAGD HPVELLARDF EKNYNMYIFP VHWQFGQLDQ
   241  HPIDGYLSHT ELAPLRAPLI PMEHCTTRFF ETCDLDNDKY IALDEWAGCF GIKQKDIDKD
   301  LVI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPARC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
2,047 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 2,047 nTPM
  • adipose tissue: 1,559 nTPM
  • ovary: 1,492 nTPM
  • gallbladder: 1,426 nTPM
  • blood vessel: 1,378 nTPM
  • smooth muscle: 1,167 nTPM

Single-cell type

  • hepatic stellate cells: 3,983 nCPM
  • platelets: 2,264 nCPM
  • decidual stromal cells: 1,466 nCPM
  • peritubular myoid cells: 1,058 nCPM
  • pericytes: 992 nCPM
  • endometrial stromal cells: 974 nCPM

Immune cell

  • total PBMC: 124 nTPM
  • neutrophil: 25 nTPM
  • basophil: 10 nTPM
  • classical monocyte: 8.7 nTPM
  • eosinophil: 2.7 nTPM
  • myeloid DC: 2.3 nTPM

Brain region

  • hypothalamus: 3,295 nTPM
  • medulla oblongata: 2,846 nTPM
  • midbrain: 2,637 nTPM
  • pons: 2,251 nTPM
  • white matter: 2,208 nTPM
  • thalamus: 2,168 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SPARC.

Disease | AllUniProt

Conditions SPARC is implicated in, by any mechanism.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 271 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.89
gnomAD missense Z
1.1
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPARC as an antibody target. Whether an autoantibody or antibody against SPARC could matter depends on whether native SPARC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPARC is annotated as secreted, so native SPARC circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SPARC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPARC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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