Seroatlas · Human Serome Atlas

SPANXN5

Sperm protein associated with the nucleus on the X chromosome N5

Also known as: CT11.10, SPANX-N5, SPXN5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5MJ07
Gene
SPANXN5
Ensembl
ENSG00000204363
Chromosome
X
Canonical length
72 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for SPANXN5 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

72 residues, UniProt reviewed canonical sequence.

>Q5MJ07|SPANXN5
     1  MEKPTSSTNG EKRKSPCDSN SKNDEMQETP NRDLVLEPSL KKMKTSEYST VLVLCYRKTK
    61  KIHSNQLEND QS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPANXN5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • testis: 38 nTPM
  • placenta: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • early spermatids: 347 nCPM
  • late primary spermatocytes: 164 nCPM
  • late spermatids: 111 nCPM
  • sertoli cells: 2.5 nCPM
  • leydig cells: 1.4 nCPM
  • differentiating spermatogonia: 0.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.9
gnomAD pLI
0.09
gnomAD missense Z
-0.18
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPANXN5 as an antibody target. Whether an autoantibody or antibody against SPANXN5 could matter depends on whether native SPANXN5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPANXN5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPANXN5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPANXN5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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