SPANXN4
Sperm protein associated with the nucleus on the X chromosome N4
Also known as: CT11.9, SPANX-N4, SPXN4_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5MJ08
- Gene
- SPANXN4
- Ensembl
- ENSG00000189326
- Chromosome
- X
- Canonical length
- 99 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nuclear membrane,Vesicles,Plasma membrane
OverviewNCBI Gene
This gene represents one of several duplicated family members that are located on the X chromosome. This gene family encodes proteins that play a role in spermiogenesis. These proteins represent a specific subgroup of cancer/testis-associated antigens, and they may be candidates for tumor vaccines. This family member belongs to a subgroup of related genes that are present in all primates and rats and mice, and thus, it represents one of the ancestral family members. [provided by RefSeq, Sep 2009]
Canonical amino-acid sequenceUniProt
99 residues, UniProt reviewed canonical sequence.
>Q5MJ08|SPANXN4
1 MEEPTSSTNE NKMKSPCESN KRKVDKKKKN LHRASAPEQS LKETEKAKYP TLVFYCRKNK
61 KRNSNQLENN QPTESSTDPI KEKGDLDISA GSPQDGGQNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SPANXN4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.73
- Highest tissue expression
- 25 nTPM
Expression across tissuesHPA
Tissue
- testis: 25 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
Single-cell type
- late spermatids: 366 nCPM
- early spermatids: 94 nCPM
- late primary spermatocytes: 26 nCPM
- platelets: 2.8 nCPM
- adipocytes: 0.8 nCPM
- granulosa cells: 0.8 nCPM
Immune cell
- neutrophil: 0.1 nTPM
- total PBMC: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- hippocampal formation: 0.9 nTPM
- amygdala: 0.5 nTPM
- basal ganglia: 0.3 nTPM
- cerebral cortex: 0.3 nTPM
- white matter: 0.2 nTPM
- hypothalamus: 0.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.81
- gnomAD pLI
- 0.35
- gnomAD missense Z
- -1.3
- DepMap mean gene effect
- 0.11
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SPANXN4 as an antibody target. Whether an autoantibody or antibody against SPANXN4 could matter depends on whether native SPANXN4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SPANXN4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SPANXN4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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