SPANXN2
Sperm protein associated with the nucleus on the X chromosome N2
Also known as: CT11.7, SPANX-N2, SPXN2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5MJ10
- Gene
- SPANXN2
- Ensembl
- ENSG00000268988
- Chromosome
- X
- Canonical length
- 180 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli fibrillar center
OverviewNCBI Gene
No narrative summary is available for SPANXN2 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
180 residues, UniProt reviewed canonical sequence.
>Q5MJ10|SPANXN2
1 MEQPTSSTNG EKRKSPCESN NKKNDEMQEA PNRVLAPKQS LQKTKTIEYL TIIVYYYRKH
61 TKINSNQLEK DQSRENSINP VQEEEDEGLD SAEGSSQEDE DLDSSEGSSQ EDEDLDSSEG
121 SSQEDEDLDS SEGSSQEDED LDSSEGSSQE DEDLDPPEGS SQEDEDLDSS EGSSQEGGEDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SPANXN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.69
- Highest tissue expression
- 3.3 nTPM
Expression across tissuesHPA
Tissue
- testis: 3.3 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
Single-cell type
- late spermatids: 161 nCPM
- early spermatids: 63 nCPM
- late primary spermatocytes: 7.2 nCPM
- leydig cells: 0.5 nCPM
- early primary spermatocytes: 0.3 nCPM
- undifferentiated spermatogonia: 0.2 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.89
- gnomAD pLI
- 0.09
- gnomAD missense Z
- -0.32
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
InteractionsUniProt · HPA
Protein binding partners of SPANXN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SPANXN2 as an antibody target. Whether an autoantibody or antibody against SPANXN2 could matter depends on whether native SPANXN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SPANXN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SPANXN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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