SPANXD
Sperm protein associated with the nucleus on the X chromosome D
Also known as: CT11.4, SPANXE, SPNXD_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BXN6
- Gene
- SPANXD
- Ensembl
- ENSG00000196406
- Chromosome
- X
- Canonical length
- 97 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Vesicles
OverviewNCBI Gene
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a sperm protein that is associated with the nucleus but, although a role in spermatogenesis is suggested, the specific function of this family member has not yet been determined. Polymorphisms in this gene may be associated with prostate cancer susceptibility. [provided by RefSeq, Apr 2014]
Canonical amino-acid sequenceUniProt
97 residues, UniProt reviewed canonical sequence.
>Q9BXN6|SPANXD
1 MDKQSSAGGV KRSVPCDSNE ANEMMPETSS GYSDPQPAPK KLKTSESSTI LVVRYRRNFK
61 RTSPEELVND HARKNRINPL QMEEEEFMEI MVEIPAKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SPANXD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.62
- Highest tissue expression
- 21 nTPM
Expression across tissuesHPA
Tissue
- testis: 21 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
Single-cell type
- late spermatids: 2,101 nCPM
- early spermatids: 472 nCPM
- late primary spermatocytes: 158 nCPM
- sertoli cells: 4.5 nCPM
- leydig cells: 1.4 nCPM
- peritubular myoid cells: 1.3 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 3.3 nTPM
- hypothalamus: 3.3 nTPM
- white matter: 2.8 nTPM
- pons: 2.7 nTPM
- hippocampal formation: 2.6 nTPM
- basal ganglia: 2.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.92
- gnomAD pLI
- 0.08
- gnomAD missense Z
- -3.54
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SPANXD as an antibody target. Whether an autoantibody or antibody against SPANXD could matter depends on whether native SPANXD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SPANXD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SPANXD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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