SPANXC
Sperm protein associated with the nucleus on the X chromosome C
Also known as: CT11.3, CTp11, SPNXC_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NY87
- Gene
- SPANXC
- Ensembl
- ENSG00000198573
- Chromosome
- X
- Canonical length
- 97 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Vesicles
OverviewNCBI Gene
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family, which is located in a gene cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a protein that localizes to the nucleus and is expressed in highly metastatic cell lines, making the protein a potential diagnostic and prognostic marker. The protein belongs to a family of cancer/testis antigens and represents a potential target for cancer immunotherapy. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
97 residues, UniProt reviewed canonical sequence.
>Q9NY87|SPANXC
1 MDKQSSAGGV KRSVPCDSNE ANEMMPETSS GYSDPQPAPK KLKTSESSTI LVVRYRRNVK
61 RTSPEELVND HARENRINPL QMEEEEFMEI MVEIPAKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SPANXC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.6
- Highest tissue expression
- 30 nTPM
Expression across tissuesHPA
Tissue
- testis: 30 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
Single-cell type
- late spermatids: 2,257 nCPM
- early spermatids: 473 nCPM
- late primary spermatocytes: 141 nCPM
- sertoli cells: 4 nCPM
- peritubular myoid cells: 2.9 nCPM
- leydig cells: 2 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- hypothalamus: 1.9 nTPM
- white matter: 1.3 nTPM
- cerebral cortex: 1 nTPM
- pons: 1 nTPM
- thalamus: 1 nTPM
- medulla oblongata: 0.9 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.92
- gnomAD pLI
- 0.07
- gnomAD missense Z
- -2.49
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SPANXC as an antibody target. Whether an autoantibody or antibody against SPANXC could matter depends on whether native SPANXC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SPANXC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SPANXC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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