Seroatlas · Human Serome Atlas

SPANXA2-OT1

Putative uncharacterized protein SPANXA2-OT1

Also known as: SPOT1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N9U9
Gene: SPANXA2-OT1
Canonical length: 137 aa

OverviewNCBI Gene

No narrative summary is available for SPANXA2-OT1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

137 residues, UniProt reviewed canonical sequence.

>Q8N9U9|SPANXA2-OT1
     1  MASPFGRLTD QKGRGHPAGS GGVEVNGGSA RAAFSGGGRR VLSGGGRTAF GGGGRTAFGD
    61  GGRTAFGVGG RTAFGGGGRT AFGGGGRTAF GVGGRTAFGG GERVSLLSPG WSALARSWLT
   121  ASSASRVQAI LLPQPPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPANXA2-OT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPANXA2-OT1 as an antibody target. Whether an autoantibody or antibody against SPANXA2-OT1 could matter depends on whether native SPANXA2-OT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPANXA2-OT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPANXA2-OT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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