Seroatlas · Human Serome Atlas

SPAG7

Sperm-associated antigen 7

Also known as: ACRP, FSA-1, MGC20134, SPAG7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75391
Gene: SPAG7
Ensembl: ENSG00000091640
Chromosome: 17
Canonical length: 227 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable nucleic acid binding activity. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

227 residues, UniProt reviewed canonical sequence.

>O75391|SPAG7
     1  MADLLGSILS SMEKPPSLGD QETRRKAREQ AARLKKLQEQ EKQQKVEFRK RMEKEVSDFI
    61  QDSGQIKKKF QPMNKIERSI LHDVVEVAGL TSFSFGEDDD CRYVMIFKKE FAPSDEELDS
   121  YRRGEEWDPQ KAEEKRKLKE LAQRQEEEAA QQGPVVVSPA SDYKDKYSHL IGKGAAKDAA
   181  HMLQANKTYG CVPVANKRDT RSIEEAMNEI RAKKRLRQSG EELPPTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPAG7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 286 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 286 nTPM
tongue: 201 nTPM
heart muscle: 159 nTPM
kidney: 91 nTPM
choroid plexus: 77 nTPM
liver: 71 nTPM

Single-cell type

syncytiotrophoblasts: 272 nCPM
extravillous trophoblasts: 247 nCPM
cytotrophoblasts: 215 nCPM
migrating cytotrophoblasts: 214 nCPM
decidual stromal cells: 192 nCPM
hofbauer cells: 172 nCPM

Immune cell

plasmacytoid DC: 106 nTPM
myeloid DC: 104 nTPM
memory B-cell: 98 nTPM
basophil: 96 nTPM
naive CD4 T-cell: 96 nTPM
T-reg: 95 nTPM

Brain region

pons: 46 nTPM
medulla oblongata: 45 nTPM
white matter: 45 nTPM
cerebellum: 44 nTPM
thalamus: 44 nTPM
cerebral cortex: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 0.88
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

nucleic acid binding

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

R3H domain
R3H domain superfamily
R3H domain
Sperm-associated antigen 7
Sperm-associated antigen 7, R3H domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPAG7 as an antibody target. Whether an autoantibody or antibody against SPAG7 could matter depends on whether native SPAG7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPAG7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPAG7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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