Seroatlas · Human Serome Atlas

SPAG17

Sperm-associated antigen 17

Also known as: CT143, FLJ34497, PF6, RP4-776P7.2, SPG17_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6Q759
Gene
SPAG17
Ensembl
ENSG00000155761
Chromosome
1
Canonical length
2223 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Equatorial segment,Mid piece,Principal piece

OverviewNCBI Gene

This gene encodes a central pair protein present in the axonemes of cells with a """"""""""""""""""""""""""""""""9 + 2"""""""""""""""""""""""""""""""" organization of microtubules. The encoded protein is required for the proper function of the axoneme. Mutations in the orthologous gene in mice lead to primary ciliary dyskinesia characterized by immotile nasal and tracheal cilia, reduced clearance of nasal mucus, profound respiratory distress, hydrocephalus, and neonatal lethality within twelve hours of birth due to impaired airway mucociliary clearance. Single-nucleotide polymorphisms in this gene are associated with human height and targeted mutations lead to skeletal malformations affecting the limbs in mice, suggesting a role for this gene in skeletal development. [provided by RefSeq, Feb 2017]

Canonical amino-acid sequenceUniProt

2223 residues, UniProt reviewed canonical sequence.

>Q6Q759|SPAG17
     1  MAPKKEKGGT VNTSSKIWEP SLIAAQFNQN DWQASIAFVV GNQIEDDLLI QALTVAVQVP
    61  QRKLFSMVSW QDILQQINEI NTLVGSASSK KAKKPVGGNA PLYYEVLTAA KAIMDSGEKL
   121  TLPLIGKLLK FQLLQIKFKD QQRRENEKKV IEDKPKLEKD KGKAKSPKEK KAPSAKPAKG
   181  KGKDQPEANA PVKKTTQLKR RGEDDHTNRY IDDEPDDGAQ HYIIVVGFNN PQLLAIMAEL
   241  GIPITSVIKI SSENYEPLQT HLAAVNQQQE VLLQSEDLEA EKLKKENAIK ELKTFWKYLE
   301  PVLNNEKPET NLFDVARLEY MVKAADFPSD WSDGEMMLKL GTDIFENIAC LMYDILDWKR
   361  QHQHYLESMQ LINVPQVVNE KPVLEAMPTS EAPQPAVPAP GKKKAQYEEP QAPPPVTSVI
   421  TTEVDMRYYN YLLNPIREEF ISVPLILHCM LEQVVATEED LVPPSLREPS PRADGLDHRI
   481  AAHIVSLLPS LCLSEREKKN LHDIFLSEEE NESKAVPKGP LLLNYHDAHA HKKYALQDQK
   541  NFDPVQIEQE MQSKLPLWEF LQFPLPPPWN NTKRLATIHE LMHFCTSDVL SWNEVERAFK
   601  VFTFESLKLS EVDEKGKLKP SGMMCGSDSE MFNIPWDNPA RFAKQIRQQY VMKMNTQEAK
   661  QKADIKIKDR TLFVDQNLSM SVQDNESNRE PSDPSQCDAN NMKHSDLNNL KLSVPDNRQL
   721  LEQESIMKAQ PQHESLEQTT NNEIKDDAVT KADSHEKKPK KMMVEADLED IKKTQQRSLM
   781  DWSFTEHFKP KVLLQVLQEA HKQYRCVDSY YHTQDNSLLL VFHNPMNRQR LHCEYWNIAL
   841  HSNVGFRNYL ELVAKSIQDW ITKEEAIYQE SKMNEKIIRT RAELELKSSA NAKLTSASKI
   901  FSIKESKSNK GISKTEISDQ EKEKEKEKIP FILEGSLKAW KEEQHRLAEE ERLREEKKAE
   961  KKGKEAGKKK GKDNAEKEDS RSLKKKSPYK EKSKEEQVKI QEVTEESPHQ PEPKITYPFH
  1021  GYNMGNIPTQ ISGSNYYLYP SDGGQIEVEK TMFEKGPTFI KVRVVKDNHN FMIHLNDPKE
  1081  IVKKEEKGDY YLEEEEEGDE EQSLETEVSD AKNKAFSKFG SFSATLENGI CLSISYYGSN
  1141  GMAPEDKDPD LETILNIPSA LTPTVVPVIV TVPQSKAKGK IKGKEKPKES LKEEEHPKEE
  1201  EKKEEEVEPE PVLQETLDVP TFQSLNVSCP SGLLLTFIGQ ESTGQYVIDE EPTWDIMVRQ
  1261  SYPQRVKHYE FYKTVMPPAE QEASRVITSQ GTVVKYMLDG STQILFADGA VSRSPNSGLI
  1321  CPPSEMPATP HSGDLMDSIS QQKSETIPSE ITNTKKGKSH KSQSSMAHKG EIHDPPPEAV
  1381  QTVTPVEVHI GTWFTTTPEG NRIGTKGLER IADLTPLLSF QATDPVNGTV MTTREDKVVI
  1441  VERKDGTRIV DHADGTRITT FYQVYEDQII LPDDQETTEG PRTVTRQVKC MRVESSRYAT
  1501  VIANCEDSSC CATFGDGTTI IAKPQGTYQV LPPNTGSLYI DKDCSAVYCH ESSSNIYYPF
  1561  QKREQLRAGR YIMRHTSEVI CEVLDPEGNT FQVMADGSIS TILPEKKLED DLNEKTEGYD
  1621  SLSSMHLEKN HQQIYGEHVP RFFVMYADGS GMELLRDSDI EEYLSLAYKE SNTVVLQEPV
  1681  QEQPGTLTIT VLRPFHEASP WQVKKEDTIV PPNLRSRSWE TFPSVEKKTP GPPFGTQIWK
  1741  GLCIESKQLV SAPGAILKSP SVLQMRQFIQ HEVIKNEVKL RLQVSLKDYI NYILKKEDEL
  1801  QEMMVKDSRT EEERGNAADL LKLVMSFPKM EETTKSHVTE VAAHLTDLFK QSLATPPKCP
  1861  PDTFGKDFFE KTWRHTASSK RWKEKIDKTR KEIETTQNYL MDIKNRIIPP FFKSELNQLY
  1921  QSQYNHLDSL SKKLPSFTKK NEDANETAVQ DTSDLNLDFK PHKVSEQKSS SVPSLPKPEI
  1981  SADKKDFTAQ NQTENLTKSP EEAESYEPVK IPTQSLLQDV AGQTRKEKVK LPHYLLSSKP
  2041  KSQPLAKVQD SVGGKVNTSS VASAAINNAK SSLFGFHLLP SSVKFGVLKE GHTYATVVKL
  2101  KNVGVDFCRF KVKQPPPSTG LKVTYKPGPV AAGMQTELNI ELFATAVGED GAKGSAHISH
  2161  NIEIMTEHEV LFLPVEATVL TSSNYDKRPK DFPQGKENPM VQRTSTIYSS TLGVFMSRKV
  2221  SPH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPAG17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 26 nTPM
  • testis: 14 nTPM
  • fallopian tube: 7.9 nTPM
  • esophagus: 5.8 nTPM
  • epididymis: 4.2 nTPM
  • pituitary gland: 3.8 nTPM

Single-cell type

  • ependymal cells: 1,673 nCPM
  • respiratory ciliated cells: 1,268 nCPM
  • endometrial ciliated cells: 874 nCPM
  • choroid plexus epithelial cells: 722 nCPM
  • fallopian tube ciliated cells: 684 nCPM
  • epididymal efferent duct ciliated cells: 675 nCPM

Immune cell

  • myeloid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • choroid plexus: 56 nTPM
  • midbrain: 19 nTPM
  • medulla oblongata: 16 nTPM
  • spinal cord: 11 nTPM
  • pons: 7.5 nTPM
  • white matter: 6.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SPAG17.

Disease | AllUniProt

Conditions SPAG17 is implicated in, by any mechanism.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 375 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.63
gnomAD pLI
0
gnomAD missense Z
0.08
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Sperm-associated antigen 17
  • Flagellar-associated PapD-like

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPAG17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPAG17 as an antibody target. Whether an autoantibody or antibody against SPAG17 could matter depends on whether native SPAG17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPAG17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPAG17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPAG17. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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