Seroatlas · Human Serome Atlas

SPAG11B

Sperm-associated antigen 11B

Also known as: EDDM2B, EP2, EP2C, EP2D, HE2, SG11B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q08648
Gene: SPAG11B
Ensembl: ENSG00000164871
Chromosome: 8
Canonical length: 103 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Golgi apparatus
Secretome location: Secreted in male reproductive system

OverviewNCBI Gene

This gene encodes several androgen-dependent, epididymis-specific secretory proteins. The specific functions of these proteins have not been determined, but they are thought to be involved in sperm maturation. Some of the isoforms contain regions of similarity to beta-defensins, a family of antimicrobial peptides. The gene is located on chromosome 8p23 near the defensin gene cluster. Alternative splicing of this gene results in seven transcript variants encoding different isoforms. Two different N-terminal and five different C-terminal protein sequences are encoded by the splice variants. Two additional variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

103 residues, UniProt reviewed canonical sequence.

>Q08648|SPAG11B
     1  MRQRLLPSVT SLLLVALLFP GSSQARHVNH SATEALGELR ERAPGQGTNG FQLLRHAVKR
    61  DLLPPRTPPY QVHISHREAR GPSFRICVDF LGPRWARGCS TGN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPAG11B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 1,188 nTPM

Expression across tissuesHPA

Tissue

epididymis: 1,188 nTPM
fallopian tube: 0.6 nTPM
seminal vesicle: 0.3 nTPM
retina: 0.2 nTPM
cervix: 0.1 nTPM
esophagus: 0.1 nTPM

Single-cell type

epididymal principal cells: 7,109 nCPM
epididymal efferent duct absorptive cells: 435 nCPM
epididymal efferent duct ciliated cells: 21 nCPM
epididymal basal cells: 13 nCPM
epididymal clear cells: 8.2 nCPM
retinal pigment epithelial cells: 4.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 0.9 nTPM
choroid plexus: 0.8 nTPM
cerebral cortex: 0.7 nTPM
white matter: 0.7 nTPM
hypothalamus: 0.6 nTPM
midbrain: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0.03
gnomAD missense Z: -0.9

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPAG11B as an antibody target. Whether an autoantibody or antibody against SPAG11B could matter depends on whether native SPAG11B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPAG11B is annotated as secreted, so native SPAG11B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SPAG11B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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