SPAG11A
Sperm-associated antigen 11A
Also known as: EDDM2A, HE2, SG11A_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6PDA7
- Gene
- SPAG11A
- Ensembl
- ENSG00000178287
- Chromosome
- 8
- Canonical length
- 123 aa
- Protein class
- Predicted intracellular proteins, Predicted secreted proteins
- Subcellular location
- Golgi apparatus
- Secretome location
- Secreted in male reproductive system
OverviewNCBI Gene
This gene encodes several androgen-dependent, epididymis-specific secretory proteins. The specific functions of these proteins have not been determined, but they are thought to be involved in sperm maturation. Some of the isoforms contain regions of similarity to beta-defensins, a family of antimicrobial peptides. The gene is located on chromosome 8p23 near the defensin gene cluster. Alternative splicing of this gene results in seven transcript variants encoding different isoforms. Two different N-terminal and five different C-terminal protein sequences are encoded by the splice variants. Two additional variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
123 residues, UniProt reviewed canonical sequence.
>Q6PDA7|SPAG11A
1 MRQRLLPSVT SLLLVALLFP GSSQARHVNH SATEALGELR ERAPGQGTNG FQLLRHAVKR
61 DLLPPRTPPY QVHISHQEAR GPSFKICVGF LGPRWARGCS TGNEKYHLPY AARDLQTFFL
121 PFWLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SPAG11A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.63
- Highest tissue expression
- 4,487 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 4,487 nTPM
- fallopian tube: 0.3 nTPM
- seminal vesicle: 0.3 nTPM
- esophagus: 0.1 nTPM
- testis: 0.1 nTPM
- adipose tissue: 0 nTPM
Single-cell type
- epididymal principal cells: 4,478 nCPM
- epididymal efferent duct absorptive cells: 94 nCPM
- epididymal basal cells: 31 nCPM
- epididymal clear cells: 20 nCPM
- mast cells: 8.7 nCPM
- epididymal efferent duct ciliated cells: 7.1 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- basal ganglia: 0.3 nTPM
- cerebral cortex: 0.3 nTPM
- thalamus: 0.3 nTPM
- medulla oblongata: 0.2 nTPM
- pons: 0.2 nTPM
- midbrain: 0.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.95
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.14
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SPAG11A as an antibody target. Whether an autoantibody or antibody against SPAG11A could matter depends on whether native SPAG11A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SPAG11A is annotated as secreted, so native SPAG11A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label SPAG11A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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