Seroatlas · Human Serome Atlas

SPADH

CUB domain-containing protein

Also known as: SPADH_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A494C103
Gene: SPADH
Canonical length: 137 aa

OverviewNCBI Gene

No narrative summary is available for SPADH in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

137 residues, UniProt reviewed canonical sequence.

>A0A494C103|SPADH
     1  MRLSRAFAWP LLCSIATTVK APFATAPSDC GGHYTDEYGR IFNYAGPKTE CVWIIELNPG
    61  EIVTVAIPDL KGFACGKEYV EVLDGPPGSE SLDRICKAFS TFYYSSSNII TIKYSREPSH
   121  PPTFFEIYYF VDAWSTH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPADH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPADH as an antibody target. Whether an autoantibody or antibody against SPADH could matter depends on whether native SPADH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPADH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPADH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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