Seroatlas · Human Serome Atlas

SPACDR

Sperm acrosome developmental regulator

Also known as: C7orf61, IMAGE:4839025, SACDR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZ16
Gene: SPACDR
Ensembl: ENSG00000185955
Chromosome: 7
Canonical length: 206 aa
Protein class: Disease related genes, Predicted intracellular proteins
Subcellular location: Vesicles,Acrosome

OverviewNCBI Gene

Involved in spermatid development. Located in acrosomal vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

206 residues, UniProt reviewed canonical sequence.

>Q8IZ16|SPACDR
     1  MVVVMKFFRW VRRAWQRIIS WVFFWRQKIK PTISGHPDSK KHSLKKMEKT LQVVETLRLV
    61  ELPKEAKPKL GESPELADPC VLAKTTEETE VELGQQGQSL LQLPRTAVKS VSTLMVSALQ
   121  SGWQMCSWKS SVSSASVSSQ VRTQSPLKTP EAELLWEVYL VLWAVRKHLR RLYRRQERHR
   181  RHHVRCHAAP RPNPAQSLKL DAQSPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPACDR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 66 nTPM

Expression across tissuesHPA

Tissue

testis: 66 nTPM
midbrain: 9.2 nTPM
spinal cord: 8.6 nTPM
basal ganglia: 8 nTPM
hippocampal formation: 7.6 nTPM
amygdala: 6.2 nTPM

Single-cell type

early spermatids: 556 nCPM
late spermatids: 448 nCPM
late primary spermatocytes: 437 nCPM
neutrophils: 34 nCPM
astrocytes: 28 nCPM
epididymal basal cells: 21 nCPM

Immune cell

T-reg: 0.6 nTPM
naive CD8 T-cell: 0.3 nTPM
neutrophil: 0.3 nTPM
classical monocyte: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM
NK-cell: 0.2 nTPM

Brain region

white matter: 19 nTPM
basal ganglia: 16 nTPM
cerebral cortex: 14 nTPM
medulla oblongata: 14 nTPM
midbrain: 14 nTPM
pons: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0.02
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

spermatid development

Cellular components

Protein domainsUniProt · Pfam · InterPro

Sperm acrosome developmental regulator
Domain of unknown function (DUF4703)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPACDR as an antibody target. Whether an autoantibody or antibody against SPACDR could matter depends on whether native SPACDR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPACDR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPACDR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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