SPACA7
Sperm acrosome-associated protein 7
Also known as: C13orf28, SPAC7_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96KW9
- Gene
- SPACA7
- Ensembl
- ENSG00000153498
- Chromosome
- 13
- Canonical length
- 195 aa
- Protein class
- Predicted intracellular proteins, Predicted secreted proteins
- Subcellular location
- Microtubules,Mitochondria,Acrosome,Equatorial segment,Principal piece,End piece
- Secretome location
- Secreted in male reproductive system
OverviewNCBI Gene
Predicted to act upstream of or within negative regulation of cell adhesion and single fertilization. Located in acrosomal vesicle. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
195 residues, UniProt reviewed canonical sequence.
>Q96KW9|SPACA7
1 MAVSQGDGTL CFVLLLCCWQ ETELRPRTVI PGSPTEIPFS SKQEDMSELL DEILVQEILD
61 LNKTTPSEMP STASTLSTPL HAGIDENYQA GGSENYHELL ENLQFSPGIE VKISNDEANA
121 NANLHGDPSE NYRGPQVSPG SEKSVSSKEK NSKNTQYENL SILDQILQNI GRSSGNIFHK
181 EQQRTSAQRR SQGSQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SPACA7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.67
- Highest tissue expression
- 84 nTPM
Expression across tissuesHPA
Tissue
- testis: 84 nTPM
- bone marrow: 0.5 nTPM
- salivary gland: 0.3 nTPM
- liver: 0.2 nTPM
- lymph node: 0.2 nTPM
- retina: 0.2 nTPM
Single-cell type
- early spermatids: 1,323 nCPM
- late spermatids: 935 nCPM
- late primary spermatocytes: 553 nCPM
- sertoli cells: 3.1 nCPM
- leydig cells: 1.6 nCPM
- differentiating spermatogonia: 1.2 nCPM
Immune cell
- neutrophil: 1 nTPM
- basophil: 0.7 nTPM
- classical monocyte: 0.2 nTPM
- eosinophil: 0.2 nTPM
- gdT-cell: 0.1 nTPM
- intermediate monocyte: 0.1 nTPM
Brain region
- cerebellum: 4.5 nTPM
- choroid plexus: 4.4 nTPM
- cerebral cortex: 4.2 nTPM
- basal ganglia: 4 nTPM
- medulla oblongata: 4 nTPM
- white matter: 4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.41
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.12
- DepMap mean gene effect
- -0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
- acrosomal vesicle
- extracellular region
- acrosomal lumen
Protein domainsUniProt · Pfam · InterPro
- Sperm acrosome-associated protein 7
- Sperm acrosome-associated protein 7
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SPACA7 as an antibody target. Whether an autoantibody or antibody against SPACA7 could matter depends on whether native SPACA7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SPACA7 is annotated as secreted, so native SPACA7 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label SPACA7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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