Seroatlas · Human Serome Atlas

SPACA6

Sperm acrosome membrane-associated protein 6

Also known as: LET7EH, LINC00085, NCRNA00085, SACA6_HUMAN, SPACA6P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: W5XKT8
Gene: SPACA6
Ensembl: ENSG00000182310
Chromosome: 19
Canonical length: 324 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables protein-macromolecule adaptor activity. Involved in sperm-egg recognition. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

324 residues, UniProt reviewed canonical sequence.

>W5XKT8|SPACA6
     1  MALLALASAV PSALLALAVF RVPAWACLLC FTTYSERLRI CQMFVGMRSP KLEECEEAFT
    61  AAFQGLSDTE INYDERSHLH DTFTQMTHAL QELAAAQGSF EVAFPDAAEK MKKVITQLKE
   121  AQACIPPCGL QEFARRFLCS GCYSRVCDLP LDCPVQDVTV TRGDQAMFSC IVNFQLPKEE
   181  ITYSWKFAGG GLRTQDLSYF RDMPRAEGYL ARIRPAQLTH RGTFSCVIKQ DQRPLARLYF
   241  FLNVTGPPPR AETELQASFR EVLRWAPRDA ELIEPWRPSL GELLARPEAL TPSNLFLLAV
   301  LGALASASAT VLAWMFFRWY CSGN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPACA6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 6.2 nTPM

Expression across tissuesHPA

Tissue

testis: 6.2 nTPM
blood vessel: 2.7 nTPM
cerebellum: 2.7 nTPM
endometrium: 2.7 nTPM
fallopian tube: 2.7 nTPM
cervix: 2.2 nTPM

Single-cell type

epicardial cells: 2,174 nCPM
mesothelial cells: 353 nCPM
neutrophils: 125 nCPM
salivary myoepithelial cells: 108 nCPM
early spermatids: 102 nCPM
salivary basal cells: 68 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 7.1 nTPM
cerebellum: 6.9 nTPM
pons: 6.2 nTPM
midbrain: 5.7 nTPM
thalamus: 5.5 nTPM
cerebral cortex: 5.3 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein-macromolecule adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Immunoglobulin-like domain
Immunoglobulin-like fold
Immunoglobulin-like domain superfamily
Sperm acrosome membrane-associated protein 6

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPACA6 as an antibody target. Whether an autoantibody or antibody against SPACA6 could matter depends on whether native SPACA6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPACA6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPACA6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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