Seroatlas · Human Serome Atlas

SP9

Transcription factor Sp9

Also known as: SP9_HUMAN, ZNF990

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CG40
Gene: SP9
Ensembl: ENSG00000217236
Chromosome: 2
Canonical length: 484 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Mitochondria

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

484 residues, UniProt reviewed canonical sequence.

>P0CG40|SP9
     1  MATSILGEEP RFGTTPLAML AATCNKIGNT SPLTTLPESS AFAKGGFHPW KRSSSSCNLG
    61  SSLSGFAVAT GGRGSGGLAG GSGAANSAFC LASTSPTSSA FSSDYGGLFS NSAAAAAAAA
   121  GVSPQEAGGQ SAFISKVHTT AADGLYPRVG MAHPYESWYK SGFHSTLAAG EVTNGAASSW
   181  WDVHSSPGSW LEVQNPAGGL QSSLHSGAPQ ASLHSQLGTY NPDFSSLTHS AFSSTGLGSS
   241  AAAASHLLST SQHLLAQDGF KPVLPSYSDS SAAVAAAAAS AMISGAAAAA AGGSSARSAR
   301  RYSGRATCDC PNCQEAERLG PAGASLRRKG LHSCHIPGCG KVYGKTSHLK AHLRWHTGER
   361  PFVCNWLFCG KRFTRSDELQ RHLRTHTGEK RFACPVCNKR FMRSDHLSKH IKTHNGGGGG
   421  KKGSDSDTDA SNLETPRSES PDLILHDSGV SAARAAAAAA AAAAAAAAAA SAGGKEAASG
   481  PNDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SP9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 3.9 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 3.9 nTPM
cerebral cortex: 3.3 nTPM
amygdala: 2.4 nTPM
fallopian tube: 1.7 nTPM
hypothalamus: 1.3 nTPM
hippocampal formation: 1.1 nTPM

Single-cell type

brain inhibitory neurons: 6.4 nCPM
respiratory ionocytes: 5.1 nCPM
other brain neurons: 2.5 nCPM
fibroblasts: 1.4 nCPM
gastric progenitor cells: 1.3 nCPM
vascular smooth muscle cells: 0.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 8.2 nTPM
cerebral cortex: 7.5 nTPM
amygdala: 7.2 nTPM
hypothalamus: 6.1 nTPM
white matter: 3.2 nTPM
thalamus: 3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SP9.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 70 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Intellectual disability
Epileptic encephalopathy
Abnormal caudate nucleus morphology
EEG abnormality
Hypotonia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.34
gnomAD pLI: 0.94
gnomAD missense Z: 2.26
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SP9 as an antibody target. Whether an autoantibody or antibody against SP9 could matter depends on whether native SP9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SP9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SP9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...