Seroatlas · Human Serome Atlas

SP8

Transcription factor Sp8

Also known as: SP8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IXZ3
Gene: SP8
Ensembl: ENSG00000164651
Chromosome: 7
Canonical length: 490 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is an SP family transcription factor that in mouse has been shown to be essential for proper limb development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Canonical amino-acid sequenceUniProt

490 residues, UniProt reviewed canonical sequence.

>Q8IXZ3|SP8
     1  MLAATCNKIG SPSPSPSSLS DSSSSFGKGF HPWKRSSSSS SASCNVVGSS LSSFGVSGAS
    61  RNGGSSSAAA AAAAAAAAAA ALVSDSFSCG GSPGSSAFSL TSSSAAAAAA AAAAAASSSP
   121  FANDYSVFQA PGVSGGSGGG GGGGGGGSSA HSQDGSHQPV FISKVHTSVD GLQGIYPRVG
   181  MAHPYESWFK PSHPGLGAAG EVGSAGASSW WDVGAGWIDV QNPNSAAALP GSLHPAAGGL
   241  QTSLHSPLGG YNSDYSGLSH SAFSSGASSH LLSPAGQHLM DGFKPVLPGS YPDSAPSPLA
   301  GAGGSMLSAG PSAPLGGSPR SSARRYSGRA TCDCPNCQEA ERLGPAGASL RRKGLHSCHI
   361  PGCGKVYGKT SHLKAHLRWH TGERPFVCNW LFCGKRFTRS DELQRHLRTH TGEKRFACPV
   421  CNKRFMRSDH LSKHVKTHSG GGGGGGSAGS GSGGKKGSDT DSEHSAAGSP PCHSPELLQP
   481  PEPGHRNGLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SP8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 6 nTPM

Expression across tissuesHPA

Tissue

prostate: 6 nTPM
skin: 0.8 nTPM
cerebral cortex: 0.6 nTPM
amygdala: 0.3 nTPM
small intestine: 0.3 nTPM
hippocampal formation: 0.2 nTPM

Single-cell type

basal prostatic cells: 16 nCPM
prostatic glandular cells: 14 nCPM
undifferentiated spermatogonia: 2.3 nCPM
brain inhibitory neurons: 2.2 nCPM
prostatic hillock cells: 2.2 nCPM
early primary spermatocytes: 2.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 11 nTPM
medulla oblongata: 8.8 nTPM
hypothalamus: 7.4 nTPM
basal ganglia: 5.7 nTPM
amygdala: 3.1 nTPM
hippocampal formation: 3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 0.97
gnomAD missense Z: 1.69
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SP8 as an antibody target. Whether an autoantibody or antibody against SP8 could matter depends on whether native SP8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SP8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SP8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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