Seroatlas · Human Serome Atlas

SP6

Transcription factor Sp6

Also known as: Epfn, KLF14, SP6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q3SY56
Gene
SP6
Ensembl
ENSG00000189120
Chromosome
17
Canonical length
376 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Mitotic spindle,Centrosome

OverviewNCBI Gene

SP6 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

376 residues, UniProt reviewed canonical sequence.

>Q3SY56|SP6
     1  MLTAVCGSLG SQHTEAPHAS PPRLDLQPLQ TYQGHTSPEA GDYPSPLQPG ELQSLPLGPE
    61  VDFSQGYELP GASSRVTCED LESDSPLAPG PFSKLLQPDM SHHYESWFRP THPGAEDGSW
   121  WDLHPGTSWM DLPHTQGALT SPGHPGALQA GLGGYVGDHQ LCAPPPHPHA HHLLPAAGGQ
   181  HLLGPPDGAK ALEVAAPESQ GLDSSLDGAA RPKGSRRSVP RSSGQTVCRC PNCLEAERLG
   241  APCGPDGGKK KHLHNCHIPG CGKAYAKTSH LKAHLRWHSG DRPFVCNWLF CGKRFTRSDE
   301  LQRHLQTHTG TKKFPCAVCS RVFMRSDHLA KHMKTHEGAK EEAAGAASGE GKAGGAVEPP
   361  GGKGKREAEG SVAPSN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 21 nTPM
  • skin: 14 nTPM
  • seminal vesicle: 9.7 nTPM
  • parathyroid gland: 5.8 nTPM
  • esophagus: 5.4 nTPM
  • small intestine: 4.5 nTPM

Single-cell type

  • syncytiotrophoblasts: 108 nCPM
  • cytotrophoblasts: 70 nCPM
  • esophageal apical cells: 37 nCPM
  • migrating cytotrophoblasts: 35 nCPM
  • breast lactating cells: 25 nCPM
  • enterocytes: 14 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • pons: 1.9 nTPM
  • medulla oblongata: 1.2 nTPM
  • spinal cord: 1 nTPM
  • cerebellum: 0.9 nTPM
  • midbrain: 0.9 nTPM
  • hypothalamus: 0.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SP6.

Disease | AllUniProt

Conditions SP6 is implicated in, by any mechanism.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 56 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.76
gnomAD pLI
0.15
gnomAD missense Z
1.34
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SP6 as an antibody target. Whether an autoantibody or antibody against SP6 could matter depends on whether native SP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SP6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SP6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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