Seroatlas · Human Serome Atlas

SP5

Transcription factor Sp5

Also known as: SP5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6BEB4
Gene: SP5
Ensembl: ENSG00000204335
Chromosome: 2
Canonical length: 398 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within bone morphogenesis and post-anal tail morphogenesis. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

398 residues, UniProt reviewed canonical sequence.

>Q6BEB4|SP5
     1  MAAVAVLRND SLQAFLQDRT PSASPDLGKH SPLALLAATC SRIGQPGAAA PPDFLQVPYD
    61  PALGSPSRLF HPWTADMPAH SPGALPPPHP SLGLTPQKTH LQPSFGAAHE LPLTPPADPS
   121  YPYEFSPVKM LPSSMAALPA SCAPAYVPYA AQAALPPGYS NLLPPPPPPP PPPTCRQLSP
   181  NPAPDDLPWW SIPQAGAGPG ASGVPGSGLS GACAGAPHAP RFPASAAAAA AAAAALQRGL
   241  VLGPSDFAQY QSQIAALLQT KAPLAATARR CRRCRCPNCQ AAGGAPEAEP GKKKQHVCHV
   301  PGCGKVYGKT SHLKAHLRWH TGERPFVCNW LFCGKSFTRS DELQRHLRTH TGEKRFACPE
   361  CGKRFMRSDH LAKHVKTHQN KKLKVAEAGV KREDARDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 6 nTPM

Expression across tissuesHPA

Tissue

cervix: 6 nTPM
skin: 4.4 nTPM
endometrium: 3 nTPM
stomach: 3 nTPM
adipose tissue: 2.4 nTPM
vagina: 2.1 nTPM

Single-cell type

decidual stromal cells: 17 nCPM
epididymal clear cells: 16 nCPM
gastric chief cells: 12 nCPM
epididymal basal cells: 12 nCPM
parietal cells: 11 nCPM
undifferentiated spermatogonia: 6.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 5.2 nTPM
thalamus: 4.2 nTPM
hypothalamus: 3.5 nTPM
midbrain: 3.5 nTPM
choroid plexus: 1.6 nTPM
amygdala: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0.52
gnomAD missense Z: -0.02
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SP5 as an antibody target. Whether an autoantibody or antibody against SP5 could matter depends on whether native SP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SP5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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