Seroatlas · Human Serome Atlas

SOX8

Transcription factor SOX-8

Also known as: SOX8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P57073
Gene
SOX8
Ensembl
ENSG00000005513
Chromosome
16
Canonical length
446 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the cognitive disability found in an alpha-thalassemia-related syndrome (ART-16). This protein is also highly expressed in the majority of human hepatocellular carcinomas and promotes cellular proliferation and enhanced tumor growth. [provided by RefSeq, Jul 2017]

Canonical amino-acid sequenceUniProt

446 residues, UniProt reviewed canonical sequence.

>P57073|SOX8
     1  MLDMSEARSQ PPCSPSGTAS SMSHVEDSDS DAPPSPAGSE GLGRAGVAVG GARGDPAEAA
    61  DERFPACIRD AVSQVLKGYD WSLVPMPVRG GGGGALKAKP HVKRPMNAFM VWAQAARRKL
   121  ADQYPHLHNA ELSKTLGKLW RLLSESEKRP FVEEAERLRV QHKKDHPDYK YQPRRRKSAK
   181  AGHSDSDSGA ELGPHPGGGA VYKAEAGLGD GHHHGDHTGQ THGPPTPPTT PKTELQQAGA
   241  KPELKLEGRR PVDSGRQNID FSNVDISELS SEVMGTMDAF DVHEFDQYLP LGGPAPPEPG
   301  QAYGGAYFHA GASPVWAHKS APSASASPTE TGPPRPHIKT EQPSPGHYGD QPRGSPDYGS
   361  CSGQSSATPA APAGPFAGSQ GDYGDLQASS YYGAYPGYAP GLYQYPCFHS PRRPYASPLL
   421  NGLALPPAHS PTSHWDQPVY TTLTRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SOX8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
93 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 93 nTPM
  • midbrain: 76 nTPM
  • hippocampal formation: 72 nTPM
  • basal ganglia: 63 nTPM
  • amygdala: 58 nTPM
  • cerebral cortex: 58 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 162 nCPM
  • müller glia: 157 nCPM
  • oligodendrocytes: 112 nCPM
  • schwann cells: 28 nCPM
  • bergmann glia: 19 nCPM
  • myosatellite cells: 18 nCPM

Immune cell

  • naive CD4 T-cell: 0.3 nTPM
  • naive CD8 T-cell: 0.2 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • white matter: 217 nTPM
  • basal ganglia: 147 nTPM
  • midbrain: 125 nTPM
  • medulla oblongata: 114 nTPM
  • cerebral cortex: 113 nTPM
  • thalamus: 106 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SOX8.

Disease | ImmuneIEDB

Conditions an epitope on SOX8 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0.67
gnomAD missense Z
0.89
DepMap mean gene effect
0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SOX8 as an antibody target. Whether an autoantibody or antibody against SOX8 could matter depends on whether native SOX8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SOX8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SOX8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SOX8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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