Seroatlas · Human Serome Atlas

SOX21

Transcription factor SOX-21

Also known as: SOX21_HUMAN, SOX25

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y651
Gene: SOX21
Ensembl: ENSG00000125285
Chromosome: 13
Canonical length: 276 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

SRY-related HMG-box (SOX) genes encode a family of DNA-binding proteins containing a 79-amino acid HMG (high mobility group) domain that shares at least 50% sequence identity with the DNA-binding HMG box of the SRY protein (MIM 480000). SOX proteins are divided into 6 subgroups based on sequence similarity within and outside of the HMG domain. For additional background information on SOX genes, see SOX1 (MIM 602148).[supplied by OMIM, Apr 2004]

Canonical amino-acid sequenceUniProt

276 residues, UniProt reviewed canonical sequence.

>Q9Y651|SOX21
     1  MSKPVDHVKR PMNAFMVWSR AQRRKMAQEN PKMHNSEISK RLGAEWKLLT ESEKRPFIDE
    61  AKRLRAMHMK EHPDYKYRPR RKPKTLLKKD KFAFPVPYGL GGVADAEHPA LKAGAGLHAG
   121  AGGGLVPESL LANPEKAAAA AAAAAARVFF PQSAAAAAAA AAAAAAGSPY SLLDLGSKMA
   181  EISSSSSGLP YASSLGYPTA GAGAFHGAAA AAAAAAAAAG GHTHSHPSPG NPGYMIPCNC
   241  SAWPSPGLQP PLAYILLPGM GKPQLDPYPA AYAAAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SOX21 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

stomach: 33 nTPM
skin: 15 nTPM
amygdala: 12 nTPM
basal ganglia: 11 nTPM
cerebral cortex: 9.8 nTPM
esophagus: 9.6 nTPM

Single-cell type

foveolar cells: 102 nCPM
oligodendrocyte progenitor cells: 32 nCPM
respiratory secretory cells: 31 nCPM
mucous neck cells: 29 nCPM
respiratory deuterosomal cells: 28 nCPM
conjunctival goblet cells: 20 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 18 nTPM
thalamus: 18 nTPM
amygdala: 17 nTPM
basal ganglia: 17 nTPM
hypothalamus: 16 nTPM
spinal cord: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.73
gnomAD pLI: 0.71
gnomAD missense Z: 1.74
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SOX21 as an antibody target. Whether an autoantibody or antibody against SOX21 could matter depends on whether native SOX21 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SOX21 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SOX21 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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