SOX12

Protein identityUniProt · HPA

UniProt accession

O15370

Gene

SOX12

Ensembl

ENSG00000177732

Chromosome

20

Canonical length

315 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm

OverviewNCBI Gene

Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains, and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types. [provided by RefSeq, Jan 2013]

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>O15370|SOX12
     1  MVQQRGARAK RDGGPPPPGP GPAEEGAREP GWCKTPSGHI KRPMNAFMVW SQHERRKIMD
    61  QWPDMHNAEI SKRLGRRWQL LQDSEKIPFV REAERLRLKH MADYPDYKYR PRKKSKGAPA
   121  KARPRPPGGS GGGSRLKPGP QLPGRGGRRA AGGPLGGGAA APEDDDEDDD EELLEVRLVE
   181  TPGRELWRMV PAGRAARGQA ERAQGPSGEG AAAAAAASPT PSEDEEPEEE EEEAAAAEEG
   241  EEETVASGEE SLGFLSRLPP GPAGLDCSAL DRDPDLQPPS GTSHFEFPDY CTPEVTEMIA
   301  GDWRPSSIAD LVFTY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SOX12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.63

Highest tissue expression

16 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.47

gnomAD pLI

0.86

gnomAD missense Z

1.79

DepMap mean gene effect

0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• brain development
• camera-type eye morphogenesis
• negative regulation of transcription by RNA polymerase II
• neuron differentiation
• positive regulation of regulatory T cell differentiation
• positive regulation of transcription by RNA polymerase II
• spinal cord development

Molecular functions

• DNA binding
• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• sequence-specific double-stranded DNA binding
• transcription cis-regulatory region binding

Cellular components

• chromatin
• nucleoplasm
• nucleus
• protein-DNA complex

Protein domainsUniProt · Pfam · InterPro

• High mobility group box domain
• Transcription factor SOX-12/11/4
• High mobility group box domain superfamily
• SRY-related HMG-box transcription factor-like
• HMG (high mobility group) box

KeywordsUniProt

• Activator
• DNA-binding
• Nucleus
• Transcription
• Transcription regulation