Seroatlas · Human Serome Atlas

SOX11

Transcription factor SOX-11

Also known as: SOX11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P35716
Gene
SOX11
Ensembl
ENSG00000176887
Chromosome
2
Canonical length
441 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Plasma membrane

OverviewNCBI Gene

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

441 residues, UniProt reviewed canonical sequence.

>P35716|SOX11
     1  MVQQAESLEA ESNLPREALD TEEGEFMACS PVALDESDPD WCKTASGHIK RPMNAFMVWS
    61  KIERRKIMEQ SPDMHNAEIS KRLGKRWKML KDSEKIPFIR EAERLRLKHM ADYPDYKYRP
   121  RKKPKMDPSA KPSASQSPEK SAAGGGGGSA GGGAGGAKTS KGSSKKCGKL KAPAAAGAKA
   181  GAGKAAQSGD YGGAGDDYVL GSLRVSGSGG GGAGKTVKCV FLDEDDDDDD DDDELQLQIK
   241  QEPDEEDEEP PHQQLLQPPG QQPSQLLRRY NVAKVPASPT LSSSAESPEG ASLYDEVRAG
   301  ATSGAGGGSR LYYSFKNITK QHPPPLAQPA LSPASSRSVS TSSSSSSGSS SGSSGEDADD
   361  LMFDLSLNFS QSAHSASEQQ LGGGAAAGNL SLSLVDKDLD SFSEGSLGSH FEFPDYCTPE
   421  LSEMIAGDWL EANFSDLVFT Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SOX11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
2.7 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 2.7 nTPM
  • hypothalamus: 1.7 nTPM
  • basal ganglia: 1.6 nTPM
  • amygdala: 1.2 nTPM
  • hippocampal formation: 1 nTPM
  • colon: 0.9 nTPM

Single-cell type

  • other brain neurons: 19 nCPM
  • oligodendrocyte progenitor cells: 16 nCPM
  • brain inhibitory neurons: 15 nCPM
  • breast secretory cells: 12 nCPM
  • breast myoepithelial cells: 10 nCPM
  • ependymal cells: 7.3 nCPM

Immune cell

  • basophil: 0.7 nTPM
  • neutrophil: 0.2 nTPM
  • NK-cell: 0.2 nTPM
  • non-classical monocyte: 0.2 nTPM
  • classical monocyte: 0.1 nTPM
  • eosinophil: 0.1 nTPM

Brain region

  • hypothalamus: 11 nTPM
  • spinal cord: 7.9 nTPM
  • white matter: 7.3 nTPM
  • midbrain: 7.1 nTPM
  • basal ganglia: 6.9 nTPM
  • medulla oblongata: 6.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SOX11.

Disease | AllUniProt

Conditions SOX11 is implicated in, by any mechanism.

  • Intellectual developmental disorder with microcephaly and with or without ocular malformations or hypogonadotropic hypogonadism (IDDMOH) MIM:615866

Disease | GeneticClinVar

86 pathogenic / likely-pathogenic of 448 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on SOX11 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.86
gnomAD missense Z
2.26
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SOX11 as an antibody target. Whether an autoantibody or antibody against SOX11 could matter depends on whether native SOX11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SOX11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SOX11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SOX11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...