Seroatlas · Human Serome Atlas

SOWAHD

Ankyrin repeat domain-containing protein SOWAHD

Also known as: ANKRD58, SWAHD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NJG2
Gene: SOWAHD
Ensembl: ENSG00000187808
Chromosome: X
Canonical length: 315 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for SOWAHD in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>A6NJG2|SOWAHD
     1  MAQLGGAANR APTASLAPTS QSLRCAPQPR PSRADTGSLG RYWGKAAAAA SREHPFPGTL
    61  MHSAAGSGRR RGALRELLGL QRAAPAGWLS EERAEELGGP SGPGSSRLCL EPREHAWILA
   121  AAEGRYEVLR ELLEAEPELL LRGDPITGYS VLHWLAKHGR HEELILVHDF ALRRGLRLDV
   181  SAPGSGGLTP LHLAALQGHD MVIKVLVGAL GADATRRDHS GHRACHYLRP DAPWRLRELS
   241  GAEEWEMESG SGCTNLNNNS SGTTAWRAAS AVGATAVETS RRVAASRTKA KDTAGSRVAQ
   301  MHSLFRHLFP SFQDR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SOWAHD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 6.7 nTPM

Expression across tissuesHPA

Tissue

spleen: 6.7 nTPM
testis: 4.8 nTPM
small intestine: 3.8 nTPM
lymph node: 2.3 nTPM
bone marrow: 2 nTPM
duodenum: 2 nTPM

Single-cell type

extravillous trophoblasts: 61 nCPM
hofbauer cells: 21 nCPM
migrating cytotrophoblasts: 12 nCPM
syncytiotrophoblasts: 9.5 nCPM
parietal cells: 8.8 nCPM
enterocytes: 8.5 nCPM

Immune cell

naive B-cell: 12 nTPM
memory B-cell: 9.1 nTPM
intermediate monocyte: 3.3 nTPM
neutrophil: 3.3 nTPM
classical monocyte: 3.1 nTPM
non-classical monocyte: 2.9 nTPM

Brain region

white matter: 3 nTPM
medulla oblongata: 2.2 nTPM
spinal cord: 2 nTPM
thalamus: 2 nTPM
pons: 1.6 nTPM
cerebral cortex: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.26
gnomAD pLI: 0.53
gnomAD missense Z: 0.78
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SOWAHD as an antibody target. Whether an autoantibody or antibody against SOWAHD could matter depends on whether native SOWAHD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SOWAHD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SOWAHD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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