Seroatlas · Human Serome Atlas

SOWAHA

Ankyrin repeat domain-containing protein SOWAHA

Also known as: ANKRD43, SWAHA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2M3V2
Gene: SOWAHA
Ensembl: ENSG00000198944
Chromosome: 5
Canonical length: 549 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for SOWAHA in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

549 residues, UniProt reviewed canonical sequence.

>Q2M3V2|SOWAHA
     1  MALAAAAAAA AAGVSQAAVL GFLQEHGGKV RNSELLSRFK PLLDAGDPRG RAARRDRFKQ
    61  FVNNVAVVKE LDGVKFVVLR KKPRPPEPEP APFGPPGAAA QPSKPTSTVL PRSASAPGAP
   121  PLVRVPRPVE PPGDLGLPTE PQDTPGGPAS EPAQPPGERS ADPPLPALEL AQATERPSAD
   181  AAPPPRAPSE AASPCSDPPD AEPGPGAAKG PPQQKPCMLP VRCVPAPATL RLRAEEPGLR
   241  RQLSEEPSPR SSPLLLRRLS VEESGLGLGL GPGRSPHLRR LSRAGPRLLS PDAEELPAAP
   301  PPSAVPLEPS EHEWLVRTAG GRWTHQLHGL LLRDRGLAAK RDFMSGFTAL HWAAKSGDGE
   361  MALQLVEVAR RSGAPVDVNA RSHGGYTPLH LAALHGHEDA AVLLVVRLGA QVHVRDHSGR
   421  RAYQYLRPGS SYALRRLLGD PGLRGTTEPD ATGGGSGSLA ARRPVQVAAT ILSSTTSAFL
   481  GVLADDLMLQ DLARGLKKSS SFSKFLSASP MAPRKKTKIR GGLPAFSEIS RRPTPGPLAG
   541  LVPSLPPTT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SOWAHA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 143 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 143 nTPM
amygdala: 81 nTPM
hippocampal formation: 67 nTPM
cerebral cortex: 54 nTPM
small intestine: 37 nTPM
duodenum: 34 nTPM

Single-cell type

enterocytes: 98 nCPM
retinal horizontal cells: 90 nCPM
epididymal clear cells: 45 nCPM
parietal cells: 42 nCPM
colonocytes: 28 nCPM
müller glia: 26 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 201 nTPM
amygdala: 123 nTPM
cerebral cortex: 117 nTPM
hippocampal formation: 97 nTPM
thalamus: 42 nTPM
white matter: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0.68
gnomAD missense Z: 0.85
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SOWAHA as an antibody target. Whether an autoantibody or antibody against SOWAHA could matter depends on whether native SOWAHA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SOWAHA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SOWAHA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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