Seroatlas · Human Serome Atlas

SOHLH2

Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2

Also known as: bHLHe81, FLJ20449, SOLH2_HUMAN, SPATA28, TEB1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NX45
Gene
SOHLH2
Ensembl
ENSG00000120669
Chromosome
13
Canonical length
425 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Vesicles
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes one of testis-specific transcription factors which are essential for spermatogenesis, oogenesis and folliculogenesis. This gene is located on chromosome 13. The proteins encoded by this gene and another testis-specific transcription factor, SOHLH1, can form heterodimers, in addition to homodimers. There is a read-through locus (GeneID: 100526761) that shares sequence identity with this gene and the upstream CCDC169 (GeneID: 728591). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

425 residues, UniProt reviewed canonical sequence.

>Q9NX45|SOHLH2
     1  MASSIICQEH CQISGQAKID ILLVGDVTVG YLADTVQKLF ANIAEVTITI SDTKEAAALL
    61  DDCIFNMVLL KVPSSLSAEE LEAIKLIRFG KKKNTHSLFV FIIPENFKGC ISGHGMDIAL
   121  TEPLTMEKMS NVVKYWTTCP SNTVKTENAT GPEELGLPLQ RSYSEHLGYF PTDLFACSES
   181  LRNGNGLELN ASLSEFEKNK KISLLHSSKE KLRRERIKYC CEQLRTLLPY VKGRKNDAAS
   241  VLEATVDYVK YIREKISPAV MAQITEALQS NMRFCKKQQT PIELSLPGTV MAQRENSVMS
   301  TYSPERGLQF LTNTCWNGCS TPDAESSLDE AVRVPSSSAS ENAIGDPYKT HISSAALSLN
   361  SLHTVRYYSK VTPSYDATAV TNQNISIHLP SAMPPVSKLL PRHCTSGLGQ TCTTHPNCLQ
   421  QFWAY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SOHLH2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • testis: 26 nTPM
  • tongue: 4.9 nTPM
  • epididymis: 2 nTPM
  • basal ganglia: 1.9 nTPM
  • colon: 1.9 nTPM
  • prostate: 1.7 nTPM

Single-cell type

  • oocytes: 410 nCPM
  • late spermatids: 125 nCPM
  • early spermatids: 61 nCPM
  • late primary spermatocytes: 53 nCPM
  • differentiating spermatogonia: 41 nCPM
  • extravillous trophoblasts: 20 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 5.4 nTPM
  • thalamus: 3.8 nTPM
  • cerebral cortex: 3.7 nTPM
  • white matter: 3.7 nTPM
  • basal ganglia: 3.5 nTPM
  • hippocampal formation: 3.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.61
gnomAD pLI
0
gnomAD missense Z
1.03
DepMap mean gene effect
0.13
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SOHLH2 as an antibody target. Whether an autoantibody or antibody against SOHLH2 could matter depends on whether native SOHLH2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SOHLH2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SOHLH2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SOHLH2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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