SOD3

Protein identityUniProt · HPA

UniProt accession

P08294

Gene

SOD3

Ensembl

ENSG00000109610

Chromosome

4

Canonical length

240 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted secreted proteins

Secretome location

Secreted to blood

Quaternary structure

Homotetramer

OverviewNCBI Gene

This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

240 residues, UniProt reviewed canonical sequence.

>P08294|SOD3
     1  MLALLCSCLL LAAGASDAWT GEDSAEPNSD SAEWIRDMYA KVTEIWQEVM QRRDDDGALH
    61  AACQVQPSAT LDAAQPRVTG VVLFRQLAPR AKLDAFFALE GFPTEPNSSS RAIHVHQFGD
   121  LSQGCESTGP HYNPLAVPHP QHPGDFGNFA VRDGSLWRYR AGLAASLAGP HSIVGRAVVV
   181  HAGEDDLGRG GNQASVENGN AGRRLACCVV GVCGPGLWER QAREHSERKK RRRESECKAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SOD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

1,059 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.67

gnomAD pLI

0

gnomAD missense Z

1.11

DepMap mean gene effect

0.1

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• removal of superoxide radicals
• response to hypoxia

Molecular functions

• copper ion binding
• heparin binding
• molecular adaptor activity
• superoxide dismutase activity

Cellular components

• extracellular exosome
• extracellular region
• extracellular space
• Golgi lumen

Protein domainsUniProt · Pfam · InterPro

• Superoxide dismutase, copper/zinc binding domain
• Superoxide dismutase, copper/zinc, binding site
• Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone
• Superoxide dismutase-like, copper/zinc binding domain superfamily
• Copper/zinc superoxide dismutase (SODC)

KeywordsUniProt

• Antioxidant
• Copper
• Disulfide bond
• Glycation
• Glycoprotein
• Golgi apparatus
• Heparin-binding
• Metal-binding
• Oxidoreductase
• Secreted
• Signal
• Zinc

InteractionsUniProt · HPA

Protein binding partners of SOD3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ATP7A